California NanoSystems Institute

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Jeffrey Zink, Ph.D.

Professor, Chemistry and Biochemistry, Inorganic Chemistry, Physical Chemistry

Member, NanoBiotechnology and Biomaterials, NanoElectronics, Photonics, Architectonics, NanoMechanical and Nanofluidic Systems, California NanoSystems Institute

Researcher, Inorganic, Nanoscience and Materials, Physical

Education:

Degrees:

Ph.D., University of Illinois, 1970

Honors and Awards:

National Science Council of Taiwan , Visiting Lecturer
SUNY Buffalo, Foster Chemistry Colloquium Lecturer
US Department of Energy Materials Sciences, Outstanding Scientific Accomplishment in Metals and Ceramic Sciences
University of Amsterdam, Invited Visiting Professor
University of Oklahoma, J. Clarence Karcher Lecturer
University of Paris, Invited Visiting Professor
Dow-Hansen Distinguished Teaching Award
John Simon Guggenheim Fellow

Contact Information:

Work Email Address:	zink@chem.ucla.edu

Work Address:	Mol Sci Bldg 2505A

Home Page:	http://www.chem.ucla.edu/dept/Faculty/zink.html/
Laboratory:	http://www.chem.ucla.edu/dept/Faculty/zink/index.html
ARR Papers:	http://www.cnsi.ucla.edu/arr/personnel-papers?personnel_id=113476

Lab Number:	1 (310) 825-8651 Laboratory
Work Phone Number:	1 (310) 825-1001 Office

Technical Research Interest:

Professor Zink and his research group work primarily in four different areas: excited state properties of large molecules; laser assisted chemical vapor deposition of nano-particles and structures; functional (optical and electrical) nano-structured materials; and nano-machines. Research on excited states is currently focused on coupled potential energy surfaces with special emphasis on photo-induced electron transfer. The research on deposition makes use of excited state properties to design molecules and direct bond-breaking to lead to desired products such as pure metals or semiconductors. Photolysis in confined spaces is used to produce nanoparticles. Studies of functional nano-materials are currently focused on energy transfer and electron transfer at the nanoscale. Active molecular components designed to produce the desired function are placed in spatially-separated regions in a onestep self-assembly process. Research on nano-machines is focused on rotating machines, oscillating "molecular impellers" and nano-valves. Unifying themes that run through all of these areas include theoretical understanding of molecular properties, materials synthesis and characterization, and spectroscopy (for measuring the excited state properties, monitoring photo-driven reactions, and observing the action of the molecular machines).

Both versatility and creativity are necessary so bring to fruition the highly interdisciplinary research comprised of diverse but interwoven parts. The research program on nano-machines is illustrative. Researchers must be able to design and synthesize entire systems such that moving parts can be attached to solid supports, energized by appropriate nano-power supplies and carry out useful work. The design of the moving components and the methods for powering the movement require fundamental theoretical understanding. Synthesizing these parts, the solid structure, and then the attachment requires experimental and synthetic skills. Measuring the action of the complete machine requires analytical skills. This research is carried out in a highly interactive environment and involves inter- and intra-departmental collaboration at UCLA, and international collaboration with colleagues in Europe and Asia. Undergraduate and graduate students and post-doctoral fellows receive a broad-based education in chemistry, materials science and nano-science.

Additional Information:

Professor Zink has been a Faculty member in the Department of Chemistry and Biochemistry since 1970. He received his B.S. degree in Chemistry at the University of Wisconsin. He came to UCLA after receiving his PhD degree from the University of Illinois under the direction of Russell S. Drago. He is a Distinguished Professor of Chemistry and a member of the California Nanosystems Institute. He has been an invited guest professor at the University of Paris VI and at the University of Amsterdam, and serves as an ACS tour speaker. He is an authority on triboluminescence, photochemistry and photophysics of metal-containing molecules, and on nanomachines, and has published almost 400 articles. His current research is focused on fundamental spectroscopic investigation of large metal-containing molecules and on design, operation and biological applications of functional nanomaterials including nanomachines such as valves and impellers.

Selected Publications:

T. Xia, M. Kovochich, M. Liong, J. I. Zink, and A. E. Nel, Cationic Polystyrene Nanosphere Toxicity Depends on Cell-Specific Endocytic and Mitochondrial Injury Pathways, ACSNANO, 2008, 2, 85-96.

Xia, T. Kovochich, M. Liong, M. Zink, J. I. Nel, A. E. , Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways, Acs Nano, 2008, 2 (1), 85-96.

Xia, T. Kovochich, M. Liong, M. Madler, L. Gilbert, B. Shi, H. B. Yeh, J. I. Zink, J. I. Nel, A. E. , Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties, Acs Nano, 2008, 2 (10), 2121-2134.

K. Patel, S. Angelos, W. R. Dichtel, A. Coskun, Y. Yang, J. I. Zink, and J. F. Stoddart, Enzyme-Responsive Snap-Top Covered Silica Nanocontainers, J. Am. Chem. Soc, 2008, 130, 2382-2383 .

Patel, K. Angelos, S. Dichtel, W. R. Coskun, A. Yang, Y. W. Zink, J. I. Stoddart, J. F. , Enzyme-responsive snap-top covered silica nanocontainers, Journal of the American Chemical Society, 2008, 130 (8), 2382-2383.

Huang, M. H. Soyez, H. M. Dunn, B. S. Zink, J. I. Sellinger, A. Brinker, C. J. , In situ fluorescence probing of the chemical and structural changes during formation of hexagonal phase cetyltrimethylammonium bromide and lamellar phase CTAB/Poly(dodecylmethacrylate) sol-gel silica thin films, Journal of Sol-Gel Science and Technology, 2008, 47 (3), 300-310.

Jie Lu 1, Eunshil Choi 2, Fuyuhiko Tamanoi 1 *, Jeffrey I. Zink 2, Light-Activated Nanoimpeller-Controlled Drug Release in Cancer Cells, Small, 2008, 4 (4), 421-426.

Johansson, E. Choi, E. Angelos, S. Liong, M. Zink, J. I. , Light-activated functional mesostructured silica, Journal of Sol-Gel Science and Technology, 2008, 46 (3), 313-322.

Lu, J. Choi, E. Tamanoi, F. Zink, J. I. , Light-activated nanoimpeller-controlled drug release in cancer cells, Small, 2008, 4 (4), 421-426.

E. Johansson, E. Choi, S. Angelos, M. Liong, and J. I. Zink, Light-activated functional mesostructured silica, J Sol-Gel Sci Technol, 2008, 46, 313-322 .

J. Lu, M. Liong, S. Sherman, T. Xia, M. Kovochich, A. E. Nel, J. I. Zink, and F. Tamanoi, Mesoporous Silica Nanoparticles for Cancer Therapy: Energy-Dependent Cellular Uptake and Delivery of Paclitaxel to Cancer Cells, Nanobiotechnol, 2008, 3, 89-95.

S. Angelos, M. Liong, E. Choi and J. I. Zink, Mesoporous Silicate Materials as Substrates for Molecular Machines and Drug Delivery, Chem. Eng. J, 2008, 137, 4-13.

Angelos, S. Liong, M. Choi, E. Zink, J. I. , Mesoporous silicate materials as substrates for molecular machines and drug delivery, Chemical Engineering Journal, 2008, 137 (1), 4-13.

Liong, M. Lu, J. Kovochich, M. Xia, T. Ruehm, S. G. Nel, A. E. Tamanoi, F. Zink, J. I. , Multifunctional inorganic nanoparticles for imaging, targeting, and drug delivery, Acs Nano, 2008, 2 (5), 889-896.

Sarah Angelos, Ying-Wei Yang, Dr., Kaushik Patel, J. Fraser Stoddart, Prof. , Jeffrey I. Zink, Prof. , Nanovalves for Drug Delivery, Angewandte Chemie International Edition, 2008, 47 (12), 2222-2226.

Valverde-Aguilar, G. Wang, X. H. Plummer, E. Lockard, J. V. Zink, J. I. Luo, Y. Weaver, M. N. Nelsen, S. F. , Tuning aryl, hydrazine radical cation electronic interactions using substitutent effects, Journal of Physical Chemistry A, 2008, 112 (32), 7332-7341.

Ow, F. P. Djurovich, P. I. Thompson, M. E. Zink, J. I. , Wavelength-dependent photofragmentation of a mixed-ligand cyclometalated Platinum(II) coordination compound in a molecular beam, Inorganic Chemistry, 2008, 47 (7), 2389-2395.

Angelos, S. Yang, Y. W. Patel, K. Stoddart, J. F. Zink, J. I. , pH-responsive supramolecular nanovalves based on cucurbit[6]uril pseudorotaxanes, Angewandte Chemie-International Edition, 2008, 47 (12), 2222-2226.

S.F. Nelsen, A.E. Konradsson, M.N. Weaver, R. M. Stephenson, J. V. Lockard, Y.Zhao, and J.I. Zink, Comparisons of Measured Rate Constants with Spectroscopically Determined Electron-Transfer Parameters, J.Phys.Chem. B, 2007, 111, 6776-6781 .

T.D. Nguyen, Y. Liu, S. Saha, K.C.-F. Leung, J.F. Stoddart, and J.I. Zink, Design and Optimization of Molecular Nanovalves Based on Redox-Switchable Bistable Rotaxanes, J. Am. Chem. Soc, 2007, 129, 626-634.

X. Wang, J. Li, M.E. Thompson, and J.I. Zink, Excited-State Distortions of Cyclometalated Ir (III) Complexes Determined from the Vibronic Structure in Luminescence Spectra, J. Am. Chem. Soc, 2007, 111, 3256-3262 .

J. Lu, M. Liong, J. Zink, and F. Tamanoi, Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs, Small, 2007, 3, 1341-1346 .

S. Angelos, E. Johansson, J.F. Stoddart, and J.I. Zink, Mesostructured Silica Supports for Functional Materials and Molecular Machines, Adv. Funct. Mater, 2007, 17, 2261-2271.

B. Dunn and J.I. Zink, Molecules in Glass: Probes, Ordered Assemblies, and Functional Materials, Acc. Chem. Res, 2007, 40, 747-755.

F. P. Ow, B. Henderson, and J.I. Zink, Multiple Photochemical Reaction Pathways in a Ni(II) Coordination Compound, Inorg. Chem, 2007, 46, 2243-2248.

E. Johansson and J. I. Zink, Nanostructured Silica Thin Films Self-Assembled with Electron Donors and Acceptors to Measure Electron Tunneling, J. Am. Chem. Soc, 2007, 129, 14437-14443.

S. Saha, K.C.F. Leung, T. Nguyen, J.F. Stoddart, and J.I. Zink, Nanovalves, Adv. Funct. Mater., 2007, 17, 685-693.

S. Angelos, E. Choi, F. Vogtle, L. DeCola, and J.I. Zink, Photo-Driven Expulsion of Molecules from Mesostructure /Silica Nanoparticles, J.Phys.Chem. C, 2007, 111, 6587-6592.

X.Wang, G.Valverde-Aguilar, M. N. Weaver, S. F. Nelsen, and J.I. Zink, Resonance Raman De-Enhancement Caused by Exited State Mixed Valence, J. Phys. Chem. A, 2007, 111, 5441-5447.

T.D. Nguyen, K.C.F. Leung, M. Liong, Y. Liu, J.F. Stoddart, and J.I. Zink, Versatile Supramolecular Nanovalves Reconfigured for Light Activation, Adv. Funct. Mater., 2007, 17, 2101-2110.

F.P. Ow, M.T. Berry, P.S. May, and J.I. Zink, Wavelength and Metal Dependence in the Photofragmentation of a Gas-Phase Lanthanide B-Diketonate Complex, J. Phys. Chem. A, 2007, 111, 4144-4149.

Lockard, J. V.; Valverde, G.; Neuhauser, D.; Zink, J. I.; Luo, Y.; Weaver, M. N.; Nelsen, S. F., "Interpretation of Unusual Absorption Bandwidths and Resonance Raman Intensities in Excited State Mixed Valence.", Journal of Physical Chemistry A, 2006, 110 (1), 57-66.

T.D. Ngyuen, K. C.-F. Leung, M. Liong, C.D. Pentecost, J.F. Stoddart and J.I. Zink, Construction of a pH-Driven Supramolecular Nanovalve, Org. Lett, 2006, 8, 3363-3366 .

Inorg. Chem, Excited-State Mixed Valence in Transition Metal Complexes, E.A. Plummer and J.I. Zink, 2006, 45, 6556-6558.

J.V. Lockard, J.I. Zink, Y. Luo, M.N. Weaver, J.W. Fowble, A.E. Konradsson, and S.F. Nelsen, Excited-State Mixed Valence in a Diisopropyl Diphenyl Hydrazine Cation, J. Am. Chem. Soc., 2006, 128, 16524-16531.

J.V. Lockard, G. Valerde, D. Neuhauser, Y. Luo, M.N. Weaver, S.F. Nelsen and J.I. Zink, Interpretation of Unusual Absorption Bandwidth and Resonance Raman Intensities in Excited State Mixed Valence, J. Am. Chem. Soc, 2006, 110, 57-66.

S.F. Nelsen, Y. Luo, M.N. Weaver, J.V. Lockard, and J.I. Zink, Optical Spectra of Protected Diamine 10-Bond-Bridged Intervalence Radical Cations Related to N,N,N’N’-Tetraalkylbenzidine, J. Org. Chem., 2006, 71, 4286-4295 .

S.F. Nelson, A.E. Konradsson, M.N. Weaver, N. Michael, I.A. Guzei, M. Gobel, R. Wortmann, J.V. Lockard and J.I. Zink, Photochemical Charge Separation within Aromatic Hydrazines and the Effect of Excited-State Intervalence Dihydrazines, J. Phys. Chem. A, 2006, 109, 10854-10861.

G. Valverde-Aguilar, X. Wang, S.F. Nelsen and J.I. Zink, Photoinduced Electron Transfer in 2-tert-Butyl-3-(Anthracen-9-yl)-2,3-Diazabicyclo[2.2.2]Octane, J. Am. Chem. Soc, 2006, 128, 6180-6185 .

P. Sierocki, H. Maas, P. Dragut, G. Richardt, F. Voegtle, L. De Cola, F. Brower and J. I. Zink, Photoisomerization of Azobenzene Derivatives in Nanostructured Silica, J. Phys. Chem. B, 2006, 110, 24390-24398 .

K. C.-F. Leung, T. D. Ngyuen, J.F. Stoddart and J.I. Zink, Supramolecular Nanovalves Controlled by Proton Abstraction and Competitive Binding, Chem. Mater, 2006, 18, 5919-5928.

M.J. Poderycki, V.A. Kickhoefer, C.S. Kaddis, S. Ravel-Fernandes, E. Johansson, and J.I. Zink, The Vault Exterior Shell is a Dynamic Structure that Allows Incorporation of Vault-Associated Proteins into its Interior, Biochem, 2006, 45, 12184.

S.F. Nelsen, M.N. Weaver, Y. Luo, J.V. Lockard and J.I. Zink, Use of the Neighboring Orbital Model for Analysis of Electronic Coupling in Class III Intervalence Compounds, Chemical Physics, 2006, 324, 195-201 .

F.P. Ow, M.T. Berry, P.S. May, and J.I. Zink, Wavelength Dependent Photofragmentation Patterns of Tris(2,2,6,6-tetramethyl-3,5-heptanedionato)Ln (III) (Ln = En, Tb, Gd) in a Molecular Beam, J. Phys. Chem. A, 2006, 110, 7751-7754 .

Saha, S.; Johansson, E.; Flood, A. H.; Tseng, H.-R.; Zink, J. I.; Stoddart, J. F., "A photoactive molecular triad as a nanoscale power supply for a supramolecular machine.", Chemistry--A European Journal, 2005, 11 (23), 6846-6858.

Nguyen, T. D.; Tseng, H.-R.; Celestre, P. C.; Flood, A. H.; Liu, Y.; Stoddart, J. F.; Zink, J. I., "A reversible molecular valve.", Proceedings of the National Academy of Sciences of the United States of America, 2005, 102 (29), 10029-10034.

Lockard, J. V.; Zink, J. I.; Trieber, D. A., II; Konradsson, A. E.; Weaver, M. N.; Nelsen, S. F., "Excited-State Mixed Valence in a Diphenyl Hydrazine Cation: Spectroscopic Consequences of Coupling and Transition Dipole Moment Orientation.", Journal of Physical Chemistry A, 2005, 109 (6), 1205-1215.

Hsueh, H.-S.; Yang, C.-T.; Zink, J. I.; Huang, M. H., "Formation of Titanium Nitride Nanoparticles within Mesoporous Silica SBA-15.", Journal of Physical Chemistry B, 2005, 109 (10), 4404-4409.

Minoofar, P. N.; Dunn, B. S.; Zink, J. I., "Multiply Doped Nanostructured Silicate Sol-Gel Thin Films: Spatial Segregation of Dopants, Energy Transfer, and Distance Measurements.", Journal of the American Chemical Society, 2005, 127 (8), 2656-2665.

Lan, E. H.; Dunn, B.; Zink, J. I., "Nanostructured systems for biological materials.", Methods in Molecular Biology (Totowa, NJ, United States), 2005, 300, 53-79.

Nelsen, S. F.; Weaver, M. N.; Zink, J. I.; Telo, J. P., "Optical Spectra of Delocalized Dinitroaromatic Radical Anions Revisited.", Journal of the American Chemical Society, 2005, 127 (30), 10611-10622.

Nelsen, S. F.; Konradsson, A. E.; Weaver, M. N.; Guzei, I. A.; Goebel, M.; Wortmann, R.; Lockard, J. V.; Zink, J. I., "Photochemical Charge Separation within Aromatic Hydrazines and the Effect of Excited-State Intervalence in Dihydrazines.", Journal of Physical Chemistry A, 2005, 109 (48), 10854-10861.

Saha, S.; Johansson, L. E.; Flood, A. H.; Tseng, H.-R.; Zink, J. I.; Stoddart, J. F., "Powering a supramolecular machine with a photoactive molecular triad.", Small , 2005, 1 (1), 87-90.

Kickhoefer, VA Garcia, Y Mikyas, Y Johansson, E Zhou, JC Raval-Fernandes, S Minoofar, P Zink, JI Dunn, B Stewart, PL Rome, LH, Engineering of vault nanocapsules with enzymatic and fluorescent properties., Proceedings of the National Academy of Sciences of the United States of America. , 2005, 102 (12), 4348-52.

, "An Operational Supramolecule Nanovalve", J. Am. Chem. Soc, 2004, 126, 3370-3371.

Hawthorne, M. F.; Zink, J. I.; Skelton, J. M.; Bayer, M. J.; Liu, C.; Livshits, E.; Baer, R.; Neuhauser, D., "Electrical or Photocontrol of the Rotary Motion of a Metallacarborane.", Science (Washington, DC, United States), 2004, 303 (5665), 1849-1851.

Rickus, J. L.; Chang, P. L.; Tobin, A. J.; Zink, J. I.; Dunn, B., "Photochemical Coenzyme Regeneration in an Enzymatically Active Optical Material.", Journal of Physical Chemistry B, 2004, 108 (26), 9325-9332.

Bailey, S.E., J.I. Zink, and S.F. Nelsen, "Contributions of symmetric and asymmetric normal coordinates to the intervalence electronic absorption and resonance Raman spectra of a strongly coupled p-phenylenediamine radical cation.", Journal of the American Chemical Society, 2003, 125 (19), 5939-5947.

Bussiere, G., C. Reber, D. Neuhauser, D.A. Walter, and J.I. Zink, "Molecular properties obtained by analysis of electronic spectra containing interference dips. Comparisons of analytical equations and exact models based on coupled potential energy surfaces.", Journal of Physical Chemistry A, 2003, 107 (9), 1258-1267.

Lockard, J.V., J.I. Zink, A.E. Konradsson, M.N. Weaver, and S.F. Nelsen, "Spectroscopic consequences of a mixed valence excited state: Quantitative treatment of a dihydrazine diradical dication.", Journal of the American Chemical Society, 2003, 125 (44), 13471-13480.

Byun, D. and J.I. Zink, "Wavelength-dependent photofragmentation and photoionization of gaseous (eta(4)-cycloocta-1,5-diene)(eta(5)-cyclopentadienyl)cobalt.", Inorganic Chemistry, 2003, 42 (14), 4308-4315.

Bitner, T.W. and J.I. Zink, "Gas-phase photofragmentation of tris(methyl vinyl ketone)tungsten(0) and the relationship to laser-assisted CVD of tungsten oxide thin films.", Inorganic Chemistry, 2002, 41 (4), 967-972.