California NanoSystems Institute

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Robin Garrell, Ph.D.

Lab Director, Garrell Lab

Professor, Chemistry and Biochemistry, Organic Chemistry

Member, NanoBiotechnology and Biomaterials, California NanoSystems Institute

Researcher, Inorganic, Nanoscience and Materials, Organic

Education:

Degrees:

Ph.D., University of Michigan, 1984

Honors and Awards:

Iota Sigma Pi, Agnes Fay Morgan Award
NSF, Presidential Young Investigator Award
UCLA, Herbert Newby McCoy Award
2007 American Microchemical Society, Benedetti-Pichler Award
2003 UCLA , Distinguished Teaching Award

Certifications:

Professional Societies:

American Association for the Advancement of Science (AAAS), Elected Fellow
American Chemical Society, American Chemical Society
Coblentz Society, Coblentz Society
International Society of Quantum Biology & Pharmacology, International Society of Quantum Biology & Pharmacology
2003 - UCLA College of Letters and Science, Chair of the Faculty
1999 Society for Applied Spectroscopy, President

Contact Information:

Email Address:	garrell@chem.ucla.edu
Work Email Address:	garrell@chem.ucla.edu

Laboratory Address:	Young Hall 4072
Work Address:	Young Hall 4077B

Laboratory:	http://www.chem.ucla.edu/dept/Organic/Garrell/Garrell_Lab.html
ARR Papers:	http://www.cnsi.ucla.edu/arr/personnel-papers?personnel_id=117162

Fax Number:	1 (310) 206-2061 Fax
Lab Number:	1 (310) 206-9434 Lab
Work Phone Number:	1 (310) 825-2496 Office

Technical Research Interest:

Professor Garrell's team develops new methods for characterizing and utilizing molecules and molecular assemblies at liquid-solid interfaces. Techniques they have pioneered include surface-enhanced Raman spectroscopy (SERS) for determining molecular orientations and conformations at metal surfaces, the quartz crystal microbalance to detect phase transitions and viscosity in thin films, and g-factor spectroscopy as a rapid probe of protein secondary structure. Quantum mechanical calculations provide further insights into the surface and intermolecular interactions of molecules in self-assembled monolayers. Garrell's team correlates the molecular structures of self-assembled monolayers and thin films with the resulting macroscopic adhesion and wetting behaviors. These interfacial phenomena are being exploited in the design and fabrication of droplet-based "digital" microfluidic devices for biosensors, proteomics and drug discovery. Digital microfluidic devices are reconfigurable, can be used to perform many identical or unique (bio)chemical manipulations simultaneously, and may incorporate optical, electrochemical and/or impedance detection.

Additional Information:

Professor Garrell received her B.S. degree in Biochemistry with Honors and Distinction from Cornell University in 1978, and Ph.D. in Macromolecular Science and Engineering from the University of Michigan in 1984. She was an Assistant Professor on the faculty of the University of Pittsburgh until 1991, when she joined the faculty of the Department of Chemistry and Biochemistry at the University of California, Los Angeles. At UCLA, she is the elected Chair of the Faculty of the College of Letters and Science, Associate Director of the Institute for Cell Mimetics in Space Exploration (CMISE), Principal Investigator of the UCLA NSF-IGERT Materials Creation Training Program, member of the Chemistry-Biology Interface Training Program Executive Board, and member of the Biomedical Engineering faculty and the California NanoSystems Institute (CNSI). Garrell's research awards have included the National Science Foundation Presidential Young Investigator Award, Herbert Newby McCoy Award for Outstanding Research at UCLA, Iota Sigma Pi Agnes Fay Morgan Award, and the 2007 Benedetti-Pichler Award in Microchemistry from the American Microchemical Society. She has also received the Hanson-Dow Award for Teaching Excellence at UCLA and the UCLA Distinguished Teaching Award. Garrell is a Fellow of the American Association for the Advancement of Science. Her research interests span bioanalytical and surface chemistry, with an emphasis on fundamentals and applications of adhesion and wetting.

Selected Publications:

Huang, F. K.; Garrell, R. L. , Treatment of Thiolate Monolayers with Ozone: Substrate and Adsorbate Oxidation and the First Detection of S-Coordinated Sulfinate, , manuscript in preparation..

Yeager, L. J.; Saeki, F.; Shelly, K.; Hawthorne, M. F.; Garrell, R. L., The Oxidative and Solvent Stability of [closo-B12H11S]3- Self-Assembled Monolayers on Gold, , manuscript in preparation.

Freitas, S. S. F.; Gordillo, R.; Saeki, F.; Cai, M.-Z.; Szafranski, C. A.; Houk, K. N.; Garrell, R.L., Proof of the Existence of Disulfides on Gold: Dimerization of Cysteine at the Water-Gold Interface, , manuscript in preparation.

Teuscher, J. H.; Huang, F. K; Garrell, R. L., Photo-oxidation of Organothiolate Monolayers on Gold: Conditions and Mechanistic Pathways, , manuscript in preparation.

Teuscher, J. H.; Chadwick, J. E.; Garrell, R. L., Observation of Solid-Solid and Solid-Liquid Phase Transitions in Thin Alkane Films on Gold with a Thickness-Shear-Mode Acoustic Device, Phys. Rev. Lett, in revision..

Huang, F. K.; Garrell, R. L. , Naphthalene 1,8-Disulfide: A Stable Disulfide on Gold, Langmuir, manuscript in preparation..

Saeki, F.; Yeager, L. J.; Shelly, K.; Hawthorne, M. F.; Garrell, R. L., Formation and Electronic Structure of [closo-B12H11S]3- Self-Assembled Monolayers on Gold, , manuscript in preparation.

Baker, B. R.; Passanante, J. J.; Garrell, R. L, Accurate Protein Secondary Structure Determination from CD and UV Spectra by g-Factor Analysis, J. Am. Chem. Soc., in revision..

Chatterjee, D. Shepherd, H. Garrell, R. L. , Electromechanical model for actuating liquids in a two-plate droplet microfluidic device, Lab Chip, 2009, 9 (9), 1219-29.

Moon, H.; Wheeler, A.R.; Garrell, R.L.; Loo, J.A.; Kim, C.-J., "An Integrated Digital Microfluidic Chip for Multiplexed Proteomic Sample Preparation and Analysis by MALDI-MS", Lab Chip , 2006, 6, 1213-1219.

Yoon, J.-Y., et al., "Using a Stirred Cell to Evaluate Conformational Changes in Proteins Adsorbed on Particles", AIChE Journal, 2005 (51), 1048-1052.

Wheeler, A. R. Moon, H. Bird, C. A. Loo, R. R. Kim, C. J. Loo, J. A. Garrell, R. L. , Digital microfluidics with in-line sample purification for proteomics analyses with MALDI-MS, Anal Chem, 2005, 77 (2), 534-40.

Evilevitch, A. Gober, J. W. Phillips, M. Knobler, C. M. Gelbart, W. M. , Measurements of DNA lengths remaining in a viral capsid after osmotically suppressed partial ejection, Biophys J, 2005, 88 (1), 751-6.

Moon, H.; Wheeler, A.R.; Garrell, R.L.; Loo, J.A.; Kim, C.-J., On-Chip Sample Preparation by Electrowetting-On-Dielectric Digital Microfluidics for Matrix Assisted Laser Desorption/Ionization Mass Spectrometry, IEEE MEMS Proceed., 2005, 859-862.

Cho, Namjun; Garrell, R. L., Surface-Enhanced Raman Spectroscopy as a Probe of the Interactions of Amino Acids and Peptides with Surfaces, In Applications of Surface-Enhanced Raman Spectroscopy, 2005, Book in Press (S. Farquharson, Ed.).

Wheeler, A. R. Moon, H. Kim, C. J. Loo, J. A. Garrell, R. L. , Electrowetting-based microfluidics for analysis of peptides and proteins by matrix-assisted laser desorption/ionization mass spectrometry, Anal Chem, 2004, 76 (16), 4833-8.

Wheeler, A.R.; Garrell, R.L.; Moon, H.; Kim, C.-J.; Loo, J.A., Electrowetting-on-Dielectric for Analysis of Peptides and Proteins by Matrix Assisted Laser Desoption/Ionization Mass Spectrometry, Dig. Solid State Sens. Act. Microsys. Workshop, 2004, 402-403.

Baker, B. R. Garrell, R. L. , G-factor analysis of protein secondary structure in solutions and thin films, Faraday Discuss, 2004, 126 (number), 209-22; discussion 245-54.

Garrell, R.L., How Best to Teach Diversity, UCLA Today, 2004, 24, 7.

Wheeler, A.R.; Moon, H.; Kim, C.-J.; Loo, J.A.; Garrell, R.L. , Integrated Sample Purification in EWOD-MALDI-MS, Proc. Micro Tot. Anal. Sys., 2004, 204-206.

Garrell RL , Self-assembled monolayers of cystine on gold. , Abstracts of Papers of the American Chemical Society, 2004, 227 (1), U853-U853.

Baker, BR Garrell, RL, g-Factor Analysis of Protein Secondary Structure in Solutions and Thin Films., Faraday Disc., 2004, 126, 209-22; discussion 245-54.

Huang, J.; Egan, V.; Guo, H.; Yoon, J.-Y.; Briseno, A. L.; Garrell, R. L.; Knobler, C. M.; Zhou, F.; Kaner, R. B., "Enantioselective Discrimination of D- and L-Phenylalanine by Chiral Polyaniline Films", Adv. Mater., 2003, 15, 1158-1161.

Shapiro, B.; Moon, H.; Garrell, R.; Kim, C.-J., "Equilibrium Behavior of Sessile Drops under Surface Tension, Applied External Fields, and Material Variations", J. Appl. Phys., 2003, 93, 5794-5811.

Nishimura, I.; Garrell, R. L.; Hedrick, M.; Iida, K.; Osher, S.; Wu, B., "Precursor Tissue Analogues (PA) as a Tissue Engineering Strategy", Tissue Engineering, 2003, 9, 77-89.

Yoon, J.-Y.; Kim, C.-J.; Garrell, R. L. , "Preventing Biomolecular Adsorption in Electrowetting-Based Biofluidic Chips", Anal. Chem., 2003, 75, 5097-5102.

Garrell, R.L.; Houk, K.N., Ahi Tuna Sashimi Napolean, What's Cooking in Chemistry: How Leading Chemists Succeed in the Kitchen, 2003, d. Bell, H.P.; Feurstein, T.; G??nther, C.T., H??lsken, S. and Lohmann, J.K., 37-71.

Shapiro, B.; Moon, H.; Garrell, R.; Kim, C.-J., Modeling of Electrowetted Surface Tension for Addressable Microfluidic Systems: Dominant Physical Effects, Material Dependences and Limiting Phenomena, MEMS 2003, 2003, MP44.

Moon, H.; Cho, S. K.; Garrell, R. L.; Kim, C.-J., "Low Voltage Electrowetting-On-Dielectric (EWOD)", J. Appl. Phys., 2002, 92, 4080-4087.

Hagerman EM, Baker BR, Garrell RL, Wu BM , Effect of surface adhesion molecules on cell morphology and spreading, Journal of Dental Research, 2002, 81, A274-A274.

Chiu SH, Rowan SJ, Cantrill SJ, Ridvan L, Ashton PR, Garrell RL, Stoddart JF , Making molecular-necklaces from rotaxanes , Tetrahedron, 2002, 58 (4), 807-814.

Chiu, S. H. Rowan, S. J. Cantrill, S. J. Glink, P. T. Garrell, R. L. Stoddart, J. F. , A rotaxane-like complex with controlled-release characteristics, Org Lett, 2000, 2 (23), 3631-4.

Chiu, S. H. Myles, D. C. Garrell, R. L. Stoddart, J. F. , Novel ether-linked secondary face-to-face 2-2' and 3-3' beta-cyclodextrin dimers, J Org Chem, 2000, 65 (9), 2792-6.

Akemi Ooka, A. Garrell, R. L. , Surface-enhanced Raman spectroscopy of DOPA-containing peptides related to adhesive protein of marine mussel, Mytilus edulis, Biopolymers, 2000, 57 (2), 92-102.