California NanoSystems Institute

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Jacob Schmidt, Ph.D.

Assistant Professor, Bioengineering

Member, Neuroengineering Training Program, NanoBiotechnology and Biomaterials, California NanoSystems Institute

Education:

Degrees:

Ph.D., University of Minnesota, 1999

Certifications:

Professional Societies:

American Physical Society, American Physical Society
Biophysical Society, Biophysical Society
Materials Research Society, Materials Research Society

Contact Information:

Work Email Address:	schmidt@seas.ucla.edu

Mailing Address:	UCLA Box 951500 Los Angeles, CA UNITED STATES

Group Home Page Redirect:	http://schmidtlab.seas.ucla.edu

Fax Number:	(310) 204-5956
Work Phone Number:	(310) 205-4451 Office (310) 267-4985 Bioengineering Main Line

Research Interests:

Nanobiotechnology; Single molecule sensing using membrane proteins; Biomimetic membranes; microfluidics; manipulation and creation of biologically-functionalized devices

Technical Research Interest:

Professor Schmidt and his group have strong interests in single molecule biophysics and bioengineering, with a focus on biological membranes and membrane proteins: 1) creation of long-lived and robust biomimetic membranes; 2) singlemolecule transport measurements of membrane proteins; 3) construction of devices and apparatus for the manipulation and study of biomimetic membranes and membrane proteins. The techniques used to pursue these interests are highly multi-disciplinary, drawing on methods of genetic cloning and manipulation, biochemistry, micromachining, low-noise electronics, and microfluidics. The group aims to advance the science and technology of membrane proteins through the development of tools and techniques enabling other researchers to perform experiments previously impossible due to limitations in technology or expertise. The group also maintains a strong interest in technology development enabling more efficient drug discovery targeted toward membrane transport and channel proteins.

Selected Publications:

Poulos, J. L. Jeon, T. J. Damoiseaux, R. Gillespie, E. J. Bradley, K. A. Schmidt, J. J. , Ion channel and toxin measurement using a high throughput lipid membrane platform, Biosens Bioelectron, 2009, 24 (6), 1806-10.

Jeon, T. J. Poulos, J. L. Schmidt, J. J. , Long-term storable and shippable lipid bilayer membrane platform, Lab Chip, 2008, 8 (10), 1742-4.

Purnell, R. F. Mehta, K. K. Schmidt, J. J. , Nucleotide identification and orientation discrimination of DNA homopolymers immobilized in a protein nanopore, Nano Lett, 2008, 8 (9), 3029-34.

Branden Brough, Brian H. Northrop, Jacob J. Schmidt, Hsian-Rong Tseng, Kendall N. Houk, J. Fraser Stoddart, and Chih-Ming Ho, "Evaluation of Synthetic Linear Motor-Molecule Actuation Energetics", PNAS, 2006, 103 (23), 8583-8588.

Tae-Joon Jeon, Noah Malmstadt, and Jacob J. Schmidt, "Hydrogel-Encapsulated Lipid Membranes", JACS, 2006, 128, 42-43.

Denise Wong, Tae-Joon Jeon and Jacob Schmidt, "Single molecule measurements of channel proteins incorporated into biomimetic polymer membranes", Nanotechnology, 2006, 17, 3710-3717.

Noah Malmstadt, Michael A. Nash, Robert F. Purnell, and Jacob J. Schmidt, Automated Formation of Lipid-Bilayer Membranes in a Microfluidic Device, Nano Lett., 2006, 6 (9), 1961-1965.

Jacob J. Schmidt., "Stochastic Sensors", Journal of Materials Chemistry, 2005, 15, 831-840.

J. Xi, J.J. Schmidt, C.D. Montemagno, Self-assembled microdevices driven by muscle, Nature Materials , 2005, 4 (2), 180.

Sanguk Kim, Tae-Joon Jeon, Amit Oberai, Duan Yang, Jacob J. Schmidt, and James U. Bowie, Transmembrane glycine zippers: Physiological and pathological roles in membrane proteins, PNAS, 2005, 102 (40), 14278.

Jacob J. Schmidt and Carlo D. Montemagno., "Bioanomechanical Systems", Annual Review of Materials Research, 2004, 34, 315-337.

D. Ho, B. Chu, J.J. Schmidt, E.K. Brooks, C.D. Montemagno, Hybrid Protein-Polymer Biomimetic Membranes, IEEE Transactions on Nanotechnology, 2004, 3 (2), 1.

M. J. Casavant, D. A. Walters, J. J. Schmidt, and R. E. Smalley, Neat macroscopic membranes of aligned carbon nanotubes, J. Appl. Phys. , 2003, 93 (5), 2153.

Haiqing Liu, Jacob Schmidt, George Bachand, Shahir Rizk, Loren Looger, Homme Hellinga, and Carlo Montemagno, Control of a biomolecular motor-powered nanodevice with an engineered chemical switch, Nature Materials, 2002, 1, 173.

Jacob Schmidt, Xingqun Jiang, and Carlo Montemagno, Force Tolerances of Hybrid Nanodevices, NanoLetters, 2002 (2), 1229.