California NanoSystems Institute

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Tim Deming, Ph.D.

Professor and Chair, Bioengineering

Co-Chair, Pilot and Collaborative Translational Clinical Studies Program

Professor, Chemistry and Biochemistry, Organic Chemistry

Member, NanoBiotechnology and Biomaterials, California NanoSystems Institute

Researcher, Nanoscience and Materials, Organic, Synthesis

Investigator, Translational Technologies and Methodologies Program (BIP)

Education:

Degrees:

Ph.D., University of California, Berkeley, 1993

Academic Experience:

Fellowships:

2002 Institut Curie, Rothschild and Mayent Foundation Fellow
1998 Alfred P. Sloan Research Fellow

Honors and Awards:

Unilever Award for Outstanding Graduate Research in Polymer Chemistry
2004 World Polymer Congress , IUPAC Macromolecular Division, Samsung-IUPAC Young Scientist Award
2003 Materials Research Society, Young Investigator Award
2000 Camille Dreyfus Teacher-Scholar Award
1999 3M , Non-Tenured Faculty Award
1998 Beckman Young Investigator Award
1997 NSF, CAREER Award
1996 UC Regents, Junior Faculty Fellow
1996 Office of Naval Research Young Investigator

Certifications:

Professional Societies:

American Chemical Society, American Chemical Society

Certification Type:

1993 NIH, National Research Service Award Postdoctoral Fellow

Contact Information:

Work Email Address:	demingt@seas.ucla.edu

Mailing Address:	UCLA Department of Bioengineering Box 951600 Los Angeles, CA
Office Address:	5121 C Engineering V

Home Page:	http://deming.seas.ucla.edu/

Work Phone Number:	(310) 204-5956 (310) 207-4450 Office

Technical Research Interest:

Research in the Deming group is focused on synthesis, processing, characterization and evaluation of biological and biomimetic materials based on polypeptides. These materials are being studied since they can be prepared from renewable resources, they can be biocompatible and biodegradable, and possess unique self-assembling properties. We utilize innovative chemistry techniques to synthesize materials with properties that rival the complexity found in biological systems. The polymers are then processed into ordered assemblies, which are characterized for both nanoscale structure as well as biological function. This interdisciplinary approach stimulates innovations and ideas which direct this research into new, exciting areas.

Additional Information:

Timothy J. Deming received a B.S. in Chemistry fom the University of California, Irvine in 1989, and graduated with a Ph.D. in Chemistry from the University of California, Berkeley, under Bruce Novak in 1993. After a NIH postdoctoral fellowship at the University of Massachusetts, Amherst with David Tirrell, he joined the faculty in the Materials Department at the University of California, Santa Barbara in 1995. Here he held a joint appointment in the Materials and Chemistry Departments where he was promoted to Associate Professor in 1999 and Full Professor in 2003. His appointment is now as the Chair of the Bioengineering Department at the University of California, Los Angeles. Current research interests include polypeptide synthesis, self-assembly of block copolypeptides, and biological activity of polypeptides, for which he has received young investigator awards from the National Science Foundation, the Office of Naval Research, The Arnold and Mabel Beckman Foundation, the Alfred P. Sloan Foundation, the Camille and Henry Dreyfus Foundation, the Materials Research Society, and the IUPAC Macromolecular Division.

Selected Publications:

Yang, C. Y. Song, B. Ao, Y. Nowak, A. P. Abelowitz, R. B. Korsak, R. A. Havton, L. A. Deming, T. J. Sofroniew, M. V. , Biocompatibility of amphiphilic diblock copolypeptide hydrogels in the central nervous system, Biomaterials, 2009, 30 (15), 2881-98.

Hanson, JA; Chang, CB; Graves, SM; Li, ZB; Mason, TG; Deming, TJ , Nanoscale double emulsions stabilized by single-component block copolypeptides, Nature, 2008, 455 (7209), 85-88.

Klok, H.A., Deming, T.J.; Gnanou, Y., Matyjaszewski, K., Leibler, L. , Macromolecular Engineering of Polypeptides using the Ring Opening Polymerization of Alpha-Amino Acid N Carboxy Anhydrides, Macromolecular Engineering, 2007, 1, 519-540.

Holowka, E. P. Sun, V. Z. Kamei, D. T. Deming, T. J. , Polyarginine segments in block copolypeptides drive both vesicular assembly and intracellular delivery, Nat Mater, 2007, 6 (1), 52-7.

Nowak, A.P., Sato. J., Breedveld, V., Deming, T.J., Hydrogel Formation in Amphiphilic Triblock Copolypeptides, Supramolecular Chemistry, 2006 (18), 429-427.

Bellomo, E.G., Deming, T.J., Monoliths of Aligned Silica-Polypeptide Hexagonal Platelets, J. Am. Chem. Soc. , 2006 (128), 2276-2279.

Deming, T.J., Polypeptide abd Polypeptide Hybrid Copolymer Synthesis via NCA Polymerization, Adv. Polym. Sci., 2006 (202), 1-8.

Schaefer, K.E., Keller, P., Deming, T.J., Thermotropic Polypeptides Bearing Side-On Mesogens, Macromolecules, 2006 (39), 19-22.

Auguste, D.T., Armes, S.P., Brzezinska, K.B., Deming, T.J., Kohn, J., Prud'homme, R.K., pH Triggered Release of Protective poly(ethyleneglycol)-b-polycation Copolymers from Liposomes, Biomaterials, 2006 (27), 2599-2608.

Cui, H.; Krikorian, V.; Thompson, J.; Nowak, A. P.; Deming, T. J.; Pochan, D. J., "Preparation and Characterization of Synthetic Polypeptide Single Crystals with Controlled Thickness", Macromolecules , 2005, 38, 7371-7377.

Holowka, EP Pochan, DJ Deming, TJ, Charged polypeptide vesicles with controllable diameter., Journal of the American Chemical Society. , 2005, 127 (35), 12423-8.

Deming, T. J. , Polypeptide Hydrogels via a Unique Assembly Mechanism, Soft Matter, 2005 (1), 28-35.

Tomczak, MM Glawe, DD Drummy, LF Lawrence, CG Stone, MO Perry, CC Pochan, DJ Deming, TJ Naik, RR, Polypeptide-templated synthesis of hexagonal silica platelets., Journal of the American Chemical Society. , 2005, 127 (36), 12577-82.