California NanoSystems Institute

Print friendly page

People

Tatiana Segura, Ph.D.

Associate Professor, Chemical and Biomolecular Engineering

Member, JCCC Cancer Cell Biology Program Area, California NanoSystems Institute

Education:

Degrees:

Ph.D., Northwestern University, 2004
B.S., UC Berkeley, 1999

Honors and Awards:

NSF, CAREER Award
National Institutes of Health, National Institutes of Health Predoctoral Biotechnology Training Grant
Northwestern University, Dissertation Henderson Fellowship
NRSA Postdoctoral Fellow

Certifications:

Professional Societies:

American Chemical Society, American Chemical Society
American Institute of Chemical Engineers, American Institute of Chemical Engineers
Society for Biomaterials , Society for Biomaterials

Contact Information:

Email Address:	tsegura@ucla.edu
Work Email Address:	tsegura@ucla.edu

Mailing Address:	UCLA Department of Chemical and Biomolecular Engineering 420 Westwood Blvd Boelter Hall 5532-C Los Angeles, CA 90095 UNITED STATES

Home Page:	http://www.chemeng.ucla.edu/TSegura/index.html

Work Phone Number:	(310) 206 3980

Research Interests:

The Segura laboratory research focuses on nucleic acid delivery strategies for tissue regeneration and adult stem cell differentiation applications. Non-viral gene delivery, which can be used to deliver any gene in the genome, is a safe, yet robust way to induce up-regulation of desired angiogenic signals; however, inefficient gene transfer has hindered the wide applicability of this approach. The Segura laboratory investigates novel approaches for gene delivery, which exploit the tissue-engineering matrix as a key player in the process of gene transfer. They use the principles of engineering, chemistry, and life sciences to develop biomaterials that can be used simultaneously as scaffolds to guide tissue regeneration, stem cell differentiation and guide efficient and controlled gene transfer.

Additional Information:

Dr. Tatiana Segura is a native of Bogotá, Colombia. She received her diploma from the Escuela Pedagogia Experimental (EPE), an experimental educational school in Bogotá, Colombia. Dr. Segura began her scientific training at the University of California, Berkeley where she received a BS in Bioengineering and a minor in Chemical Engineering. She later obtained her Ph.D in Chemical Engineering at Northwestern University. Dr. Segura pursued postdoctoral research training at the Swiss Federal Institute of Technology in Lausanne, Switzerland. She joined the Chemical and Biomolecular Engineering Department at UCLA in July 2006. Dr. Segura has received the NSF CAREER Award, "Hydrogels for Matrix-Tethered Gene Delivery."

Selected Publications:

Segura, T, Schmokel, H, Hubbell, JA, RNA Interference Targeting Hypoxia Inducible Factor 1a Prevents Postoperative Adhesions in Rats, Journal of Surgical Research (In press).

Segura, T and Hubbell, JA, Synthesis and in vitro Characterization of an ABC triblock copolymer for the delivery of siRNA, Bioconjugate Chemistry March 15 ASAP.

Ng, Q. K. T. Sutton, M. K. Soonsawad, P. Xing, L. Cheng, H. Segura, T. , Engineering Clustered Ligand Binding Into Nonviral Vectors: alpha(v)beta(3) Targeting as an Example, Molecular Therapy, 2009, 17 (5), 828-836.

Adelow, C. Segura, T. Hubbell, J. A. Frey, P. , Bioactive poly(ethylene glycol) hydrogels for modulation of the smooth muscle cell phenotype, Tissue Engineering Part A, 2008, 14 (5), 811-811.

Adeloew, C. Segura, T. Hubbell, J. A. Frey, P. , The effect of enzymatically degradable poly(ethylene glycol) hydrogels on smooth muscle cell phenotype, Biomaterials, 2008, 29 (3), 314-326.

Segura, T. Schmokel, H. Hubbell, J. A. , RNA interference targeting hypoxia inducible factor 1 alpha reduces post-operative adhesions in rats, Journal of Surgical Research, 2007, 141 (2), 162-170.

Segura, T. Hubbell, J. A. , Synthesis and in vitro characterization of an ABC triblock copolymer for siRNA delivery, Bioconjugate Chemistry, 2007, 18 (3), 736-745.

Segura, T, Anderson, BC, Chung, PH, Webber RE, Shull KR, and Shea, LD, Crosslinked Hyaluronic Acid Hydrogels: A Strategy to Functionalize and Pattern, Biomaterials, 2005, 26, 359-371.

Segura, T, Chung, PH, and Shea, LD, DNA Delivery from Hyaluronic Acid-Collagen Hydrogels: a solid phase delivery approach, Biomaterials, 2005, 26 (13), 1575-84.

Bengali, Z, Pannier, AK, Segura, T, Anderson, BC, Jang, JH, Mustoe, TA and Shea, LD, Gene delivery through cell culture substrate adsorbed DNA Complexes, Biotechnology and Bioengineering, 2005, 90 (3), 290-302.

Segura, T, Volk, MJ and Shea, LD, Substrate-Mediated DNA Delivery: Role of the Cationic Polymer Structure and Extent of Modification, Journal of Controlled Release, 2003, 93, 69-84.

Segura, T and Shea, LD, Surface-Tethered DNA Complexes for Enhanced Gene Delivery, Bioconjugate Chemistry, 2002, 13 (3), 621-9.