California NanoSystems Institute

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Lily Wu, M.D., Ph.D.

Associate Professor, Molecular & Medical Pharmacology, Urology, Pediatrics

Member, California NanoSystems Institute

Education:

Degrees:

Ph.D., Dept. of Molecular Biology Institute, UCLA, 1989

M.D.:

1989 UCLA School of Medicine, UCLA School of Medicine

Honors and Awards:

Phi Beta Kappa, UC Berkeley, Member
1994 - 1997 Howard Hughes Medical Institute , Postdoctoral Fellowship for Physician

Certifications:

Professional Societies:

American Academy of Pediatrics, American Academy of Pediatrics
American Association for Cancer Research, American Association for Cancer Research
American Association for the Advancement of Science, American Association for the Advancement of Science
American Medical Association, American Medical Association
American Society of Gene Therapy, American Society of Gene Therapy
American Society of Hematology, American Society of Hematology

Contact Information:

Work Email Address:	lwu@mednet.ucla.edu

Work Address:	Office 10833 Le Conte Ave. Los Angeles, CA 90095 UNITED STATES
Work Address:	Laboratory 10833 Le Conte Ave. Los Angeles, CA 90095 UNITED STATES

ARR Papers:	http://www.cnsi.ucla.edu/arr/personnel-papers?personnel_id=45568

Fax Number:	(310) 794-4759
Work Phone Number:	(310) 825-8511 Laboratory (310)794-4390 Office

Additional Information:

Lily Wu is a biomedical research scientist focused on developing cancer-targeted therapy. Dr. Wu has been a faculty member of the Department of Urology since 1998, and she holds joint appointments in the Department of Molecular & Medical Pharmacology and the Department of Pediatrics. Dr. Wu earned her B.S. degrees in Biochemistry and Physiology at University of California, Berkeley in 1982. She graduated in 1989 as a member of the inaugural class of Medical Scientist Training Program (M.D., Ph.D program) at UCLA. Her current research topic of gene-based cancer therapy was initiated with the support of a Howard Hughes Medical Institute Postdoctoral Fellowship for Physicians in 1994. Her diverse education training ranges from clinical disciplines of pediatrics and hematology/oncology to molecular and cellular fields such as adenovirus biology, transcription regulation, and gene therapy. Besides her research endeavors, a major part of her effort involves mentoring students at all levels, from undergraduates, graduate, postdoctoral fellows to clinical residents. Her diverse background creates a fertile ground for the interdisciplinary approaches she has taken in her research. Her main goal is to deliver safe, effective, and targeted treatment to cancer patients.

Selected Publications:

Pouliot F, Johnson M, Wu L, Non-invasive molecular imaging of lymphatic metastasis of prostate cancer. , Trends in Molecular Medicine, 2009, 15, 254-262.
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Brakenhielm E, Burton JB, Johnson M, Chavarria N, Morizono K, Chen I, Alitalo K, Wu L. , Modulating metastasis by a lymphangiogenic switch in prostate cancer., International Journal of Cancer, 121, 2153-2161.

Huyn, S. T. Burton, J. B. Sato, M. Carey, M. Gambhir, S. S. Wu, L. , A potent, imaging adenoviral vector driven by the cancer-selective mucin-1 promoter that targets breast cancer metastasis, Clin Cancer Res, 2009, 15 (9), 3126-34.

Burton, J. B. Johnson, M. Sato, M. Koh, S. B. S. Mulholland, D. J. Stout, D. Chatziioannou, A. F. Phelps, M. E. Wu, H. Wu, L. , Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer, Nature Medicine, 2008, 14 (8), 882-888.

Ray, S. Paulmurugan, R. Patel, M. R. Ahn, B. C. Wu, L. Carey, M. Gambhir, S. S. , Noninvasive imaging of therapeutic gene expression using a bidirectional transcriptional amplification strategy, Mol Ther, 2008, 16 (11), 1848-56.

Figueireido M, Kao C, Wu L, Advances in Preclinical Investigation of Prostate Cancer Gene Therapy, Mol Ther , 2007, 15, 1053-1064.

Iyer M, Salazar FB, Wu L, Carey M, Gambhir SS, "Bioluminescence Imaging of Systemic Tumor Targeting Using a Prostate-Specific Lentiviral Vector", Hum Gene Ther, 2006, 17, 125-32.

Wang Y, Iyer M, Annala A, Wu L, Carey M, Gambhir SS, "Noninvasive indirect imaging of vascular endothelial growth factor gene expression using bioluminescence imaging in living transgenic mice", Physiol Genomics, 2006, 24, 173-80.

Johnson M, Huyn S, Burton JB, Sato M, Wu L, The Differential Biodistribution of Adenoviral Vector In Vivo as Monitored by Bioluminescence Imaging and Quantitative PCR, Human Gene Therapy, 2006, 17, 1262-9.

Ilagan R, Zhang L, Pottratz J, Le K, Salas S, Iyer M, Wu L, Gambhir SS, Carey M, "Imaging Androgen Receptor Function During Anti-Androgen Treatment In Prostate Cancer Xenografts", Mol Can Ther, 2005, 4 (1662-9).

Iyer M, Salazar FB, Lewis X, Zhang L, Wu L, Carey M, Gambhir SS, "Noninvasive Imaging Of A Transgenic Mouse Model Using A Prostate-Specific Two-Step Transcriptional Amplification Strategy", Transgenic Res, 2005, 14, 47-55.

Bjorndahl MA, Cao R, Burton JB, Brakenhielm E, Religa P, Galter D, Wu L, Cao Y, "Vascular Endothelial Growth Factor A Promotes Tumoral Lymphangiogenesis and Lymphatic Metastasis", Can Res, 2005, 65 (9261-8).

Sato M, Johnson M, Zhang L, Gambhir SS, Carey M, Wu L, Functionality of androgen receptor-based gene expression imaging in hormone refractory prostate cancer., Clinical cancer research : an official journal of the American Association for Cancer Research. , 2005, 11 (10), 3743-9.
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Priceman SJ, Sung JL, Shaposhnik Z, Burton JB, Torres-Collado T, Moughon D, Johnson M, Cohen DA, Lusis AJ, Iruela-Arispe L, Wu L, Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of anti-angiogenic therapy, Blood , 2010, in press.

Morizono K, Xie Y, Ringpis G, Johnson M, Nassanian H, Lee B, Wu L, Chen ISY, Lentiviral Vector Retargeting To P-Glycoprotein On Metastatic Melanoma Via Intravenous Injection, Nature Medicine, 2005, 11, 346-352.

Johnson M, Sato M, Burton J, Gambhir SS, Carey M, Wu L, MicroPET/CT monitoring of herpes thymidine kinase suicide gene therapy in a prostate cancer xenograft: the advantage of a cell-specific transcriptional targeting approach, Molecular Imaging, 2005 (4), 463-472.
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Karanikolas BDW, Figueiredo ML, Wu L, Overexpression of EZH2 Transforms the Prostate Epithelial Cell Line BPH1, Molecular Cancer Research , 2009, 7, 1456-1465.
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Iyer M, Salazar FB, Lewis X, Zhang L, Carey M, Wu L, Gambhir SS, Noninvasive imaging of enhanced prostate-specific gene expression using a two-step transcriptional amplification-based lentivirus vector., Molecular therapy : the journal of the American Society of Gene Therapy. , 2004, 10 (3), 545-52.
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Ray, S. Paulmurugan, R. Hildebrandt, I. Iyer, M. Wu, L. Carey, M. Gambhir, S. S. , Novel bidirectional vector strategy for amplification of therapeutic and reporter gene expression, Hum Gene Ther, 2004, 15 (7), 681-90.

Wu L, Sato M, Integrated, molecular engineering approaches to develop prostate cancer gene therapy., Current gene therapy. , 2003, 3 (5), 452-67.
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Zhang L, Johnson M, Le KH, Sato M, Ilagan R, Iyer M, Gambhir SS, Wu L, Carey M, Interrogating androgen receptor function in recurrent prostate cancer., Cancer research. , 2003, 63 (15), 4552-60.

Sato M, Johnson M, Zhang L, Zhang B, Le K, Gambhir SS, Carey M, Wu L, Optimization of adenoviral vectors to direct highly amplified prostate-specific expression for imaging and gene therapy., Molecular therapy : the journal of the American Society of Gene Therapy. , 2003, 8 (5), 726-37.
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Wu L, Johnson M, Sato M, Transcriptionally targeted gene therapy to detect and treat cancer., Trends in molecular medicine. , 2003, 9 (10), 421-9.
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Zhang L, Adams JY, Billick E, Ilagan R, Iyer M, Le K, Smallwood A, Gambhir SS, Carey M, Wu L, Molecular engineering of a two-step transcription amplification (TSTA) system for transgene delivery in prostate cancer., Molecular therapy : the journal of the American Society of Gene Therapy. , 2002, 5 (3), 223-32.

Pantuck AJ, Matherly J, Zisman A, Nguyen D, Berger F, Gambhir SS, Black ME, Belldegrun A, Wu L, Optimizing prostate cancer suicide gene therapy using herpes simplex virus thymidine kinase active site variants., Human gene therapy. , 2002, 13 (7), 777-89.
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Adams JY, Sato M, Johnson M, Berger F, Gambhir S S, Carey M, Iruela-Arispe ML, Wu L., Visualization of Advanced Human Prostate Cancer Lesions in Living Mice by a Targeted Gene Transfer Vector and Optical Imaging., Nature Medicine, 2002, August, 8, 8, 891-896.
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Yaghoubi, S. S. Wu, L. Liang, Q. Toyokuni, T. Barrio, J. R. Namavari, M. Satyamurthy, N. Phelps, M. E. Herschman, H. R. Gambhir, S. S. , Direct correlation between positron emission tomographic images of two reporter genes delivered by two distinct adenoviral vectors, Gene Ther, 2001, 8 (14), 1072-80.

Iyer, M. Wu, L. Carey, M. Wang, Y. Smallwood, A. Gambhir, S. S. , Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters, Proc Natl Acad Sci U S A, 2001, 98 (25), 14595-600.