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Assistant Professor,
Microbiology, Immunology & Molecular Genetics
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Member,
California NanoSystems Institute,
JCCC Signal Transduction and Therapeutics Program Area
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Education: |
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Degrees:
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Ph.D., Harvard University, 2002
B.A., UC Santa Cruz, 1993
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Certifications: |
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Professional Societies:
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American Society of Microbiology, American Society of Microbiology
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Contact Information:
| Laboratory Address: |
Laboratory
MSB 2817
UNITED STATES
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| Work Address: |
Office
Molecular Sciences Building
Los Angeles, CA 90095
UNITED STATES
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| Work Address: |
Laboratory
Molecular Sciences Building
Los Angeles, CA 90095
UNITED STATES
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| Work Address: |
Office
MSB 2825
UNITED STATES
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Work Phone Number:
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310-206-7465
Office
310-206-7465
Office
310-206-7517
Laboratory
310-206-7517
Laboratory
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Technical Research Interest:
The Bradley lab is interested in i) identifying host proteins
that are usurped by bacterial pathogens and ii) understanding
how these interactions promote virulence. Specifically, we are
studying protein exotoxins produced by Bacillus anthracis
(the causative agent of anthrax), Campylobacter jejuni (the
most common cause of bacterial diarrhea in the U.S.), Vibrio
cholera (the causative agent of cholera), and Clostridium
deficile (responsible for most hospital-acquired diarrhea). To
better understand these interactions, our lab utilizes a number
approaches including i) proteomics, ii) chemical genetics and
iii) somatic cell genetics. We are also interested in developing
therapeutics and detection systems for bacterial pathogens
based on nanotechnology. To this end, we collaborate with a
number of labs at UCLA and nationwide.
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Additional Information:
Dr. Bradley received a B.A. in Biochemistry and Molecular Biology from U.C. Santa Cruz and a Ph.D. in Microbiology and Molecular Genetics from Harvard Medical School. He has been a member of the UCLA faculty since 2002 and is currently an Assistant Professor in the department of Microbiology, Immunology & Molecular Genetics. In addition, Dr. Bradley serves as Director for the Molecular Screening Shared Resource, a high-throughput screening facility that provides robotics for multiple applications including chemical genomics.
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Poulos, J. L. Jeon, T. J. Damoiseaux, R. Gillespie, E. J. Bradley, K. A. Schmidt, J. J. , Ion channel and toxin measurement using a high throughput lipid membrane platform, Biosensors & Bioelectronics, 2009, 24 ( 6), 1806-1810.
Cote Christopher K, DiMezzo Tracy L, Banks David J, France Bryan, Bradley Kenneth A, Welkos Susan L, Early interactions between fully virulent Bacillus anthracis and
macrophages that influence the balance between spore clearance and
development of a lethal infection., Microbes and infection / Institut Pasteur, 2008, 10 (6), 613-9.
Lee Shaoying, Deng Hongyu, Yu Fuqu, Melega William P, Damoiseaux Robert, Bradley Kenneth A, Sun Ren, Regulation of Kaposi's sarcoma-associated herpesvirus reactivation by
dopamine receptor-mediated signaling pathways., Journal of acquired immune deficiency syndromes (1999), 2008, 48 (5), 531-40.
Sanchez Ana M, Thomas Diane, Gillespie Eugene J, Damoiseaux Robert, Rogers Joseph, Saxe Jonathan P, Huang Jing, Manchester Marianne, Bradley Kenneth A, Amiodarone and bepridil inhibit anthrax toxin entry into host cells., Antimicrobial agents and chemotherapy, 2007, 51 (7), 2403-11.
Nassanian Hoorig, Sanchez Ana M, Lo Alice, Bradley Kenneth A, Lee Benhur, Efficient construction of an inverted minimal H1 promoter driven siRNA
expression cassette: facilitation of promoter and siRNA sequence
exchange., PLoS ONE, 2007, 2 (1), e767.
Visnyei, Koppany Saxe, Jonathan P. Huang, Jing Damoiseaux, Robert Bradley, Kenneth A. Prins, Robert M. Kornblum, Harley I. , Identification of small molecule inhibitors targeting brain tumor stem cells, Proceedings of the American Association for Cancer Research Annual Meeting, 2007, 48, 1312-1313.
Banks David J, Bradley Kenneth A, SILENCE: a new forward genetic technology., Nature methods, 2007, 4 (1), 51-3.
Maldonado-Arocho Francisco J, Fulcher Jennifer A, Lee Benhur, Bradley Kenneth A, Anthrax oedema toxin induces anthrax toxin receptor expression in
monocyte-derived cells., Molecular microbiology, 2006, 61 (2), 324-37.
Salles Isabelle I, Voth Daniel E, Ward Sabrina C, Averette Kathleen M, Tweten Rodney K, Bradley Kenneth A, Ballard Jimmy D, Cytotoxic activity of Bacillus anthracis protective antigen observed
in a macrophage cell line overexpressing ANTXR1., Cellular microbiology, 2006, 8 (8), 1272-81.
Ding Zhiping, Bradley Kenneth A, Amin Arnaout M, Xiong Jian-Ping, Expression and purification of functional human anthrax toxin receptor
(ATR/TEM8) binding domain from Escherichia coli., Protein expression and purification, 2006, 49 (1), 121-8.
Christman, Karen L. Requa, Michael V. Enriquez-Rios, Vanessa E. Ward, Sabrina C. Bradley, Kenneth A. Turner, Kimberly L. Maynard, Heather D. , Nanopatterned polymer films for bioconjugation, Abstracts of Papers American Chemical Society, 2006, 231, 23-PMSE.
Wang Wei, Mulakala Chandrika, Ward Sabrina C, Jung Grace, Luong Hai, Pham Duy, Waring Alan J, Kaznessis Yiannis, Lu Wuyuan, Bradley Kenneth A, Lehrer Robert I, Retrocyclins kill bacilli and germinating spores of Bacillus anthracis
and inactivate anthrax lethal toxin., The Journal of biological chemistry, 2006, 281 (43), 32755-64.
Christman Karen L, Requa Michael V, Enriquez-Rios Vanessa D, Ward Sabrina C, Bradley Kenneth A, Turner Kimberly L, Maynard Heather D, Submicron streptavidin patterns for protein assembly., Langmuir : the ACS journal of surfaces and colloids, 2006, 22 (17), 7444-50.
Banks David J, Barnajian Moshe, Maldonado-Arocho Francisco J, Sanchez Ana M, Bradley Kenneth A, Anthrax toxin receptor 2 mediates Bacillus anthracis killing of
macrophages following spore challenge., Cellular microbiology, 2005, 7 (8), 1173-85.
Bruce James W, Bradley Kenneth A, Ahlquist Paul, Young John A T, Isolation of cell lines that show novel, murine leukemia
virus-specific blocks to early steps of retroviral replication., Journal of virology, 2005, 79 (20), 12969-78.
Sánchez Ana M, Bradley Kenneth A, Anthrax toxin: can a little be a good thing?, Trends in microbiology, 2004, 12 (4), 143-5.
Bradley Kenneth A, Mogridge Jeremy, Jonah G, Rainey A, Batty Sarah, Young John A T, Binding of anthrax toxin to its receptor is similar to alpha
integrin-ligand interactions., The Journal of biological chemistry, 2003, 278 (49), 49342-7.
Bradley, K. A. Mogridge, J. Mourez, M. Collier, R. J. Young, J. A. , Identification of the cellular receptor for anthrax toxin, Nature, 2001, 414 ( 6860), 225-9.
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