California NanoSystems Institute

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Heather Maynard, Ph.D.

Associate Professor, Chemistry and Biochemistry

Member, California NanoSystems Institute, JCCC Cancer Cell Biology Program Area, NanoBiotechnology and Biomaterials

Education:

Degrees:

Ph.D., California Institute of Technology, 2001
M.S., University of California, Santa Barbara, 1995
B.S., University of North Carolina at Chapel Hill, 1992

Academic Experience:

Fellowships:

Alfred P. Sloan Research Fellow

Honors and Awards:

American Chemical Society, Women's Committee Travel Award
Amgen, Amgen New Faculty Award
NSF, Career Award
Seaborg Award
Selected as an Outstanding Emerging Investigator in Materials Chemistry
Soroptimist Society Award

Professional Societies:

Materials Research Society
Society for Biomaterials
Southern Methodist University, WCC ACS Lecturer
The American Chemical Society

Academic Experience:

Academic Experience:

American Cancer Society , Postdoctoral Fellowship

Contact Information:

Work Email Address:	maynard@chem.ucla.edu

Laboratory Address:	Mol Sci Bldg 4234
Laboratory Address:	Young Hall 4096
Work Address:	Mol Sci Bldg 4505B

Home Page:	http://www.chem.ucla.edu/dept/Faculty/maynard/

Lab Number:	1 (310) 825-7385
Work Phone Number:	1 (310) 267-5162

Technical Research Interest:

Maynard and her research group integrate synthetic polymers with biologically-derived molecules, such as peptides, proteins, and sugars, to prepare materials for applications in human medicine and nanotechnology. Specifically, polymer functionality and architecture are manipulated using controlled radical polymerization to prepare universal polymer scaffolds. Reaction of these scaffolds with amino acids and peptides to produce ligands that function as specific antagonists of cellsurface receptors are being pursued. Potential applications of the polymeric drugs include cancer treatment. Controlled radical polymerization is also used to synthesize peptide- and proteinpolymer conjugates. Polymer bioconjugates are important commercial therapeutics and arguably will become valuable building blocks of nanostructured materials. It is known that having well-defined conjugates with a specific number of monodisperse polymer chains is critical for resultant conjugate properties including bioactivity and self assembly. Maynard's group explores several new strategies to synthesize materials of this description. In addition, protein mico- and nanoarrays are prepared using reactive polymer surfaces. These surfaces allow for the conjugation of active biomolecules in specific conformations. These materials may be useful in sensors for cancer and also as biomaterial coatings to enhance cell adhesion.

Additional Information:

Prof. Heather D. Maynard received a Ph.D. from the California Institute of Technology for research in the group of Nobel Prize winner Robert Grubbs. She then moved to the laboratory of Jeffrey Hubbell at the Swiss Federal Institute of Technology (ETH) and University of Zurich, where from 2000-2002 she was an American Cancer Society Postdoctoral Fellow. Dr. Maynard joined the UCLA faculty as an Assistant Professor in August 2002 as the first Howard Reiss Career Development Chair in the Department of Chemistry and Biochemistry and as a member of the California Nanosystems Institute. Maynard is also a faculty affiliate in the Biomedical Engineering Interdepartmental Program, a member of the Center for Scalable and Integrated Nanomanufacturing, and a member of the Jonsson Comprehensive Cancer Center at UCLA. She is a faculty mentor in several training programs: the Chemistry-Biology Interface, the Materials Creation, the Nanotoxicology Research, and the Biotechnology Training Programs. For the latter she also serves as an executive committee member. Maynard develops new strategies to synthesize protein-polymer conjugates and polymeric drugs. She also creates polymer films for patterning and arraying oriented and bioactive proteins. For her research at UCLA, she has received several awards including the Amgen New Faculty Award, NSF Career Award, the Alfred P. Sloan Fellowship, and the Seaborg Award. She was also selected as an Outstanding Emerging Investigator in Materials Chemistry by the RSC. Maynard has given over eighty invited lectures including the WCC ACS Lecture at Southern Methodist University and the Plenary Lecture at the 9th Annual UNESCO/IUPAC Conference on Macromolecules in South Africa. Maynard has also been selected to participate in symposia sponsored by the US National Academy of Sciences and US National Academy of Engineering.

Selected Publications:

Chang, C. W. Bays, E. Tao, L. Alconcel, S. N. Maynard, H. D. , Differences in cytotoxicity of poly(PEGA)s synthesized by reversible addition-fragmentation chain transfer polymerization, Chem Commun (Camb), 2009 (24), 3580-2.

Christman, K. L. Schopf, E. Broyer, R. M. Li, R. C. Chen, Y. Maynard, H. D. , Positioning multiple proteins at the nanoscale with electron beam cross-linked functional polymers, J Am Chem Soc, 2009, 131 (2), 521-7.

Bays, E. Tao, L. Chang, C. W. Maynard, H. D. , Synthesis of Semitelechelic Maleimide Poly(PEGA) for Protein Conjugation By RAFT Polymerization, Biomacromolecules, 2009.

Broyer, R. M. Quaker, G. M. Maynard, H. D. , Designed amino acid ATRP initiators for the synthesis of biohybrid materials, J Am Chem Soc, 2008, 130 (3), 1041-7.

Heredia, K. L. Nguyen, T. H. Chang, C. W. Bulmus, V. Davis, T. P. Maynard, H. D. , Reversible siRNA-polymer conjugates by RAFT polymerization, Chem Commun (Camb), 2008, volume (28), 3245-7.

Li, R. C. Hwang, J. Maynard, H. D. , Reactive block copolymer scaffolds, Chem Commun (Camb), 2007, volume (35), 3631-3.

Heredia, K. L. Maynard, H. D. , Synthesis of protein-polymer conjugates, Org Biomol Chem, 2007, 5 (1), 45-53.

Hwang, J. Li, R. C. Maynard, H. D. , Well-defined polymers with activated ester and protected aldehyde side chains for bio-functionalization, J Control Release, 2007, 122 (3), 279-86.

Christman KL, Requa MV, Enriquez-Rios VE, Ward SC, Bradley KA, Turner KL, Maynard HD, Submicron Streptavidin Patterns for Protein Assembly, Langmuir, 2006, 22, 7444-7450.

Christman, K. L. Requa, M. V. Enriquez-Rios, V. D. Ward, S. C. Bradley, K. A. Turner, K. L. Maynard, H. D. , Submicron streptavidin patterns for protein assembly, Langmuir, 2006, 22 (17), 7444-50.

Li RC, Broyer RM, Maynard HD, Well-Defined Polymers with Acetal Side Chains as Reactive Scaffolds Synthesized by Atom Transfer Radical Polymerization, J. Polym. Sci, Part A; Polym. Chem., 2006, 44, 5004-5013.

Heredia KL, Maynard HD, Aminooxy-Functionalized Semitelechelic Polymers Synthesized by Atom Transfer Radical Polymerization, Polym. Prep., 2005, 46, 593-594.

Maynard HD, Hubbell JA , Discovery of a Sulfated Tetrapeptide that Binds to Vascular Endothelial Growth Factor, Acta Biomaterialia, 2005, 1, 451-459.

Heredia, K. L. Bontempo, D. Ly, T. Byers, J. T. Halstenberg, S. Maynard, H. D. , In situ preparation of protein-"smart" polymer conjugates with retention of bioactivity, J Am Chem Soc, 2005, 127 (48), 16955-60.

Heredia KL, Bontempo D, Ly T, Byers JT, Halstenberg S, Maynard HD, In-Situ Preparation of Protein-Smart Polymer Conjugates with Retention of Bioactivity, J. Am. Chem. Soc., 2005, 127, 16955-16960.

Bontempo D, Li RC, Ly T, Brubaker CE, Maynard HD , One-Step Synthesis of Low Polydispersity, Biotinylated Poly(N-isopropylacrylamide) by ATRP, Chem. Commun., 2005, 37, 4702-4704.

Bontempo, D. Li, R. C. Ly, T. Brubaker, C. E. Maynard, H. D. , One-step synthesis of low polydispersity, biotinylated poly(N-isopropylacrylamide) by ATRP, Chem Commun (Camb), 2005, volume (37), 4702-4.

Bontempo D, Maynard HD, Protein Macroinitiators for Atom Transfer Radical Polymerization, Polym. Prep., 2005, 46 (1), 78-79.

Christman KL, Maynard HD, Protein Patterning on Polymer Films Using Localized Acid Generation, Polym. Prepr., 2005, 46 (2), 1286.

Christman, K. L. Maynard, H. D. , Protein micropatterns using a pH-responsive polymer and light, Langmuir, 2005, 21 (18), 8389-93.

Bontempo, D. Maynard, H. D. , Streptavidin as a macroinitiator for polymerization: in situ protein-polymer conjugate formation, J Am Chem Soc, 2005, 127 (18), 6508-9.

Bontempo D, Maynard HD, Streptavidin as a Macroinitiator for Polymerization: In Situ Protein-Polymer Conjugate Formation, J. Am. Chem. Soc., 2005, 127, 6508-6509.

Bontempo D, Li RC, Maynard HD, Synthesis of Biotinylated Polymers by Atom Transfer Radical Polymerization and Bioconjugate Formation, Polym. Prepr., 2005, 46 (2), 435-436.

Bontempo D, Heredia KL, Fish BA, Maynard HD, Cysteine-reactive polymers synthesized by atom transfer radical polymerization for conjugation to proteins, Journal of the American Chemical Society, 2004, 126 (47), 15372-3.

Hwang J, Maynard HD, Multi-Functional Polymers Prepared by RAFT, Polym. Prepr., 2004, 45, 1083-1084.