California NanoSystems Institute

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John Miao, Ph.D.

Professor, Physics and Astronomy

Member, California NanoSystems Institute

Education:

Degrees:

Ph.D., SUNY at Stony Brook, 1999

Contact Information:

Email Address:	miao@physics.ucla.edu

Work Address:	UCLA Department of Physics & Astronomy Box 951547 3-108 Knudsen Los Angeles, CA 90095 UNITED STATES

ARR Papers:	http://www.cnsi.ucla.edu/arr/personnel-papers?personnel_id=113666
Home Page:	http://www.physics.ucla.edu/research/imaging/index.htm?
Home Page:	http://www.physics.ucla.edu/research/imaging/members/john_miao/index.htm

Work Phone Number:	(310) 206-2645

Research Interests:

My research interests lie in the interplay of physics, nanoscience and biology. I am particularly interested in developing new physical methods for quantitative imaging of nanoscale materials and biological specimens in three dimensions. I have played a major role in pioneering a three-dimensional imaging approach based upon the principle of using coherent diffraction in combination with a method of direct phase recovery called oversampling. I, together with my graduate students and postdocs, will continue to improve the spatial resolution of this imaging technique and pursue its applications in nanoscience and biology by using optical lasers, coherent X-rays and electrons.

Technical Research Interest:

My research interests lie in the interplay of physics, nanoscience and biology. I am particularly interested in developing new physical methods for quantitative imaging of nanoscale materials and biological systems in three dimensions. I have pioneered 3D coherent diffraction microscopy based upon coherent scattering in combination with a method of direct phase recovery called oversampling. I, together with my students, postdocs and collaborators, will continue to improve the spatial resolution of this imaging technique and pursue its applications in nanoscience and biology by using optical lasers, coherent X-rays and electrons. With the prospects of X-ray free electron lasers that are under rapid development worldwide, coherent diffraction microscopy can in principle be used to image non-crystalline specimens at the atomic resolution in three dimensions.

Selected Publications:

Miao, J. Ishikawa, T. Shen, Q. Earnest, T. , Extending X-ray crystallography to allow the imaging of noncrystalline materials, cells, and single protein complexes, Annu Rev Phys Chem, 2008, 59 (number), 387-410.

Changyong Song, Raymond Bergstrom, Damien Ramunno-Johnson, Huaidong Jiang, David Paterson, Martin D. de Jonge, Ian McNulty, Jooyoung Lee, Kang L. Wang, and Jianwei Miao, Nanoscale Imaging of Buried Structures with Elemental Specificity Using Resonant X-Ray Diffraction Microscopy, Physical Review Letters, 2008.

Jiang, H. Ramunno-Johnson, D. Song, C. Amirbekian, B. Kohmura, Y. Nishino, Y. Takahashi, Y. Ishikawa, T. Miao, J. , Nanoscale imaging of mineral crystals inside biological composite materials using X-ray diffraction microscopy, Phys Rev Lett, 2008, 100 (3), 038103.

Song, C. Bergstrom, R. Ramunno-Johnson, D. Jiang, H. Paterson, D. de Jonge, M. D. McNulty, I. Lee, J. Wang, K. L. Miao, J. , Nanoscale imaging of buried structures with elemental specificity using resonant x-ray diffraction microscopy, Phys Rev Lett, 2008, 100 (2), 025504.

Song, C. Jiang, H. Mancuso, A. Amirbekian, B. Peng, L. Sun, R. Shah, S. S. Zhou, Z. H. Ishikawa, T. Miao, J. , Quantitative imaging of single, unstained viruses with coherent x rays, Phys Rev Lett, 2008, 101 (15), 158101.

Lee, E. Fahimian, B. P. Iancu, C. V. Suloway, C. Murphy, G. E. Wright, E. R. Castano-Diez, D. Jensen, G. J. Miao, J. , Radiation dose reduction and image enhancement in biological imaging through equally-sloped tomography, J Struct Biol, 2008.

C. Song, D. Ramunno-Johnson, Y. Nishino, Y. Kohmura, T. Ishikawa, C.C. Chen, T.K. Lee and J. Miao, Phase Retrieval from Exactly Oversampled Diffraction Intensity Through Deconvolution, Phys. Rev. B., 2007, 75 (012102).

Miao, J. Chen, C. C. Song, C. Nishino, Y. Kohmura, Y. Ishikawa, T. Ramunno-Johnson, D. Lee, T. K. Risbud, S. H. , Three-dimensional GaN-Ga2O3 core shell structure revealed by x-ray diffraction microscopy, Phys Rev Lett, 2006, 97 (21), 215503.

J. Miao, Y. Nishino, Y. Kohmura, B. Johnson, S.H. Risbud and T. Ishikawa., "Quantitative Image Reconstructive of GaN Quantum Dots from Oversampled Diffraction Intensities Alone", Phys. Rev. Lett. , 2005.

J. Miao, C. Song, Y. Nishino, Y. Kohmura, B. Johnson and T. Ishikawa, 3D Microscopy Provides the First Deep View, IEEE Tech Digest Tranducers��s05, 2005, 1304-1305.

Y. Kohmura, Y. Nishino, T. Ishikawa and J. Miao, Effect of Fresnel Illumination on Oversampling Iteration Method, J. App. Phys. , 2005, 98 (123105).

J. Miao, F. F��rster and O. Levi, Equally Sloped Tomography with Oversampling Reconstruction, Phys. Rev. B, 2005 (052103), 72.

Miao, J. Nishino, Y. Kohmura, Y. Johnson, B. Song, C. Risbud, S. H. Ishikawa, T. , Quantitative image reconstruction of GaN quantum dots from oversampled diffraction intensities alone, Phys Rev Lett, 2005, 95 (8), 085503.

Miao, J Chapman, HN Kirz, J Sayre, D Hodgson, KO., "Taking X-ray diffraction to the limit: macromolecular structures from femtosecond X-ray pulses and diffraction microscopy of cells with synchrotron radiation", Annual review of biophysics and biomolecular structure. , 2004, 33, 157-76.

K. Robinson and J. Miao., "Three Dimensional X-ray Diffraction Microscopy", MRS Bulletin, 2004, 29, 177-181 .

J. Miao, J. Amonette, Y. Nishino, T. Ishikawa and K. O. Hodgson., "Direct Determination of the Absolute Electron Density of Nanostructured and Disordered Materials at Sub-10 nm Resolution", Phys. Rev., 2003, B 68, 012201.

G.S. Edwards, R.H. Austin, F.E. Carroll, M.L. Copeland, M.E. Couprie, W.E.Gabella, R.F. Haglund, B.A. Hooper, M.S. Hutson, E.D. Jansen, K.M. Joos, D.P. Kiehart, I. Lindau, J. Miao, H.S. Pratisto, J.H. Shen, Y. Tokutake, L. van der Meer and Aihua Xie., "Free-electron-laser-based biophysical and biomedical instrumentation", Rev. Sci. Instru., 2003, 74, 3207-45.

Y. Nishino, J. Miao and T. Ishikawa., "Image Reconstruction of Nanostructured Non-Periodic Objects Only from Oversampled Hard X-ray Diffraction Intensities", Phys. Rev. B (Rapid Commun.) , 2003, 68, 220101.

J. Miao, T. Ishikawa, E. H. Anderson and K. O. Hodgson., "Phase Retrieval of Diffraction Patterns from Non-Crystalline Samples", Phys. Rev., 2003, B 67, 174104.

Miao, J Hodgson, KO Ishikawa, T Larabell, CA LeGros, MA Nishino, Y, Imaging whole Escherichia coli bacteria by using single-particle x-ray diffraction., Proceedings of the National Academy of Sciences of the United States of America. , 2003, 100 (1), 110-2.

J. Miao, T. Ohsuna, O. Terasaki, K. O. Hodgson and M. A. O'Keefe., "Atomic Resolution Three-Dimensional Electron Diffraction Microscopy", Phys. Rev. Lett., 2002, 89, 155502.

J. Miao, T. Ishikawa, B. Johnson, E. H. Anderson, B. Lai and K. O. Hodgson., "High Resolution 3D X-ray Diffraction Microscopy", Phys. Rev. Lett., 2002, 89, 088303.