Andre Nel, M.B.Ch.B., Ph.D.
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Chief, Division of NanoMedicine,
California NanoSystems Institute
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Professor,
Medicine
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Director,
UC NanoToxicology Research Training Program
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Member,
California NanoSystems Institute,
JCCC Signal Transduction and Therapeutics Program Area
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Education: |
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Degrees:
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Ph.D., University Stellenbosch, 1987
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M.B.Ch.B.:
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1975 University of Stellenbosch, Capetown, R.S.A, Equivalent of American MD
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Certifications: |
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Certifications:
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1991 American Board of Allergy and Immunology
1989 American Board of Internal Medicine
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Honors and Awards: |
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International Nanoparticle Symposium, National Institute for Environmental Studies, Tsukuba, Japan, June 2005. Title: "The Role of Oxidative Stress and Mitochondrial Damage in Mediating the Effects of DEP and Ultrafine Particles", Keynote speaker
John Salvaggio Memorial Lectureship and Honorary Award , Recipient recognizing outstanding service to the specialty and science of Allergy and Immunology
NIH Study Section: Allergy, Immunology, and Transplantation Research Committee, NIAID 2004-2005, Chair
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Certifications: |
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Certification Type:
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NIH-funded UCLA Asthma and Allergic Disease Clinical Research, Director/PI
UC Lead Campus NanoToxicology Research Training Program, Founder/Director
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Contact Information:
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UCLA
David Geffen School of Medicine at UCLA
Department of Medicine
Division of NanoMedicine
10833 Le Conte Ave., 52-175 CHS
Los Angeles, CA 90095
UNITED STATES
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Fax Number:
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(310) 206-8107
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Work Phone Number:
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(310) 825-3718
(Assistant)
(310) 825-6620
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Technical Research Interest:
Dr. Nel's laboratory is engaged in three different but complementary types of research, namely: (i) the role of air pollutants in asthma, (ii) the decline of the immune system with aging, and (iii) nanotoxicology. The basis of all three types of research centers around the concept that oxygen can become toxic if the molecule is catalytically converted to oxygen radicals by particulate pollutants, mitochondrial dysfunction and possibly by nanoparticles. Mitochondria are cellular fuel generators and are also targeted by aging. Nanoparticles in ambient air as well as some engineered nanoparticles target and lodge in mitochondria. Oxygen radicals can lead to airway inflammation, manifesting as asthma and increased allergic responses in the lung. Clarification of the air components which are most toxic, allows regulation of those substances and development of rational treatment for adverse health effects caused by pollutants. Similar consideration have to be given to the potential toxicity of some engineered nanoparticles, which dependent on whether their chemical composition, surface size and surface reactivity may catalyze the production of oxygen radicals as the basis for their toxicity.
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Additional Information:
Andre Nel is a tenured Professor and practicing allergist/immunologist at UCLA. He runs the Cellular Immunology Activation Laboratory in the Johnson Cancer Center at UCLA. Dr. Nel obtained his M.B.,Ch.B. degree in Cape Town, South Africa, and subsequently did a post-doctoral fellowship in Immunology at MUSC, which was followed by doctoral thesis on his research. Dr. Nel's chief research interests are: (i) The role of air pollutants, including nanoparticles in asthma and atherosclerosis, with particular emphasis on the role of oxidative stress in the generation of airway and vascular inflammation ; (ii) Nanotoxicology, including nanomaterial properties that may lead to toxicity and nanomaterial safety testing. These studies are funded by personal RO1 grants from the NIH, as well as the NIAID-funded UCLA Asthma and Immunology Disease Center, of which Dr Nel is the Director. Dr. Nel is also co-director of the EPA-funded Southern California Particle Center. Dr Nel is the PI and Director of the UC lead campus for Nanotoxicology Research and Training Program. Dr. Nel is a member of the ASCI, AAAAI, AAI and the Western Association of Physicians. He served as Chair of the Allergy, Immunology, and Transplantation Research Committee, one of the NIAID Study Sections for the review of Training Grants.
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Saji George, Suman Pokhrel, Tian Xia, Benjamin Gilbert, Zhaoxia Ji, Marco Schowalter, Andreas Rosenauer, Robert Damoiseaux, Kenneth A. Bradley, Lutz Madler and Andre Nel, Use of a Rapid Cytotoxicity Screening Approach To Engineer a Safer Zinc Oxide Nanoparticle through Iron Doping, ACS Nano, 2010, 4 (1), 15-29.
Zhang, L. Wang, M. Kang, X. Boontheung, P. Li, N. Nel, A. E. Loo, J. A. , Oxidative Stress and Asthma: Proteome Analysis of Chitinase-like Proteins and FIZZ1 in Lung Tissue and Bronchoalveolar Lavage Fluid, J Proteome Res, 2009.
Nel AE, Mädler L, Velegol D, Xia T, Hoek EM, Somasundaran P, Klaessig F, Castranova V, Thompson M., Understanding biophysicochemical interactions at the nano-bio interface , Nature Materials, 2009, 8 (7), 543-57.
Jesus A. Araujo ; Berenice Barajas ; Michael Kleinman ; Xuping Wang ; Brian J. Bennett ; Ke Wei Gong ; Mohamad Navab ; Jack Harkema ; Constantinos Sioutas ; Aldons J. Lusis ; and Andre E. Nel , Ambient Particulate Pollutants in the Ultrafine Range Promote Early Atherosclerosis and Systemic Oxidative Stress , Circulation Research, 2008.
Xia, T. Kovochich, M. Liong, M. Zink, J. I. Nel, A. E. , Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways, ACS Nano, 2008, 2 ( 1), 85-96.
Xia, T. Kovochich, M. Liong, M. Madler, L. Gilbert, B. Shi, H. Yeh, J. I. Zink, J. I. Nel, A. E. , Comparison of the mechanism of toxicity of zinc oxide and cerium oxide nanoparticles based on dissolution and oxidative stress properties, ACS Nano, 2008, 2 ( 10), 2121-34.
Kim, H. J. Barajas, B. Wang, M. Nel, A. E. , Nrf2 activation by sulforaphane restores the age-related decrease of T(H)1 immunity: role of dendritic cells, J Allergy Clin Immunol, 2008, 121 ( 5), 1255-1261 e7.
Li, N. Xia, T. Nel, A. E. , The role of oxidative stress in ambient particulate matter-induced lung diseases and its implications in the toxicity of engineered nanoparticles, Free Radic Biol Med, 2008, 44 ( 9), 1689-99.
Xia T, Kovochich M, Brant J, Hotze M, Sempf J, Oberley T, Sioutas C, Yeh JI, Wiesner MR and Nel AE, Comparison of the Abilities of Ambient and Manufactured Nanoparticles to Induce Cellular Toxicity According to an Oxidative Stress Paradigm, Nano Letters, 2006, 6 (8), 1794-1807.
Nel A, Xia T, Maedler L, Li N, Toxic Potential of Materials at the Nanolevel, Science, 2006, 311 (5761), 622-627.
Nel A , "Air Polution-Related Illness: Biomolecular Effects of Particles", Science, 2005, 208, 804.
Wang M, Xiao GC, Li N, Xie Y, Loo JA and Nel AE, "Phosphorproteome and cytokine array analysis show MAP kinases mediate inflammation by pro-oxidative diesel exhaust particle chemicals", Electrophoresis, 2005, 26, 2092-2108.
Xiao GG, Nel AE, Loo JA, Nitrotyrosine-modified proteins and oxidative stress induced by diesel exhaust particles., Electrophoresis. , 2005, 26 (1), 280-92.
Xia T, Korge P, Weiss JN, Li N, Venkatesen I, Sioutas C and Nel A, "Quinones and Aromatic Chemical Compounds in Particulate Matter (PM) Induce Mitochondrial Dysfunction: Implications for PM-induced Oxidative Stress and Toxicity", Environ Health Perspectives, 2004 (112), 1347-1358.
Li N, Alam J, Venkatesan MI, Eiguren-Fernandez A, Schmitz D, Di Stefano E, Slaughter N, Killeen E, Wang X, Huang A, Wang M, Miguel AH, Cho A, Sioutas C, Nel AE, Nrf2 is a key transcription factor that regulates antioxidant defense in macrophages and epithelial cells: protecting against the proinflammatory and oxidizing effects of diesel exhaust chemicals., Journal of immunology (Baltimore, Md. : 1950) , 2004, 173 (5), 3467-81.
Li N, Hao M, Phalen RF, Hinds WC, Nel AE, Particulate air pollutants and asthma. A paradigm for the role of oxidative stress in PM-induced adverse health effects., Clinical immunology (Orlando, Fla.) , 2003, 109 (3), 250-65.
Xiao GG, Wang M, Li N, Loo JA, Nel AE, Use of proteomics to demonstrate a hierarchical oxidative stress response to diesel exhaust particle chemicals in a macrophage cell line., The Journal of biological chemistry. , 2003, 278 (50), 50781-90.
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