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Professor,
Psychiatry and Biobehavioral Sciences | |
Senior Research Scientist, Hatos Center for Neuropharmacology,
Semel Institute (NPI)
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Member,
California NanoSystems Institute
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Education: |
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Degrees:
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Ph.D., The American University, 1993
B.S., The Pennsylvania State University, 1985
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Academic Experience: |
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Fellowships:
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1989 - 1992 United States Department of Education Fellowship
1991 - 1992 NIH Predoctoral Intramural Research Training Award
1993 - 1997 NIH Postdoctoral Intramural Research Training Award
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Honors and Awards: |
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1997 - NIH Fellows Award for Research Excellence
2001 - Eli Lilly Outstanding Analytical Chemist Award
2001 - American Parkinson’s Disease Association Research Award
2007 - Sigma Xi, Scientific Research Society
2009 - NARSAD, Independent Investigator Award
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Professional Societies: |
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1992 - present Phi Lambda Upsilon National Honorary Chemical Society
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Contact Information:
| Mailing Address: |
760 Westwood Plaza 68/226A
University of California, Los Angeles
Los Angeles , CA 90095
UNITED STATES
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Fax Number:
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310-267-4918
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Work Phone Number:
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310-794-9421
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Technical Research Interest:
Andrews' research group is highly interdisciplinary and includes students with backgrounds in chemistry, neuroscience, biomedical sciences, physics, bioengineering, genetics, biochemistry, molecular biology, and medicine. Research is centered on understanding how the neurotransmitter serotonin modulates complex behaviors such as anxiety, stress responsiveness, and learning and memory. Human and nonhuman primate cell lines, genetically engineered mice, drugs, neurotoxins, and environmental factors are used to probe the molecular bases of serotonin system function and the mechanisms of drugs used to treat psychiatric disorders. Bioanalytical techniques, including microelectrode voltammetry and microdialysis are used to investigate serotonin neurotransmission. Neuronal architectures and the expression of key proteins, such as brain-derived neurotrophic factor, which are regulated by serotonin, are studied using autoradiography, immunocytochemistry, RT‑qPCR, ELISA, and Western blotting. Neurotransmitter-functionalized self-assembled materials have been designed for fundamental studies on neurotransmitter recognition by native and nonnative biomolecule binding partners and for the development of novel in vivo nanobiosensors and functionally-directed proteomics.
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Additional Information:
Born in Pittsburgh, Pennsylvania, Andrews received her B.S. in Science from the Pennsylvania State University and her Ph.D. in Chemistry from the American University. She also attended the George Washington University, Sino-Soviet Institute for Russian Area Studies. Andrews was a U.S. Department of Education Fellow and an NIH Predoctoral Intramural Research Training Award (IRTA) Fellow in the Laboratory of Clinical Science at the National Institute of Mental Health (NIMH), where she carried out her doctoral research under the direction of Dr. Dennis Murphy. Andrews continued as a Postdoctoral IRTA Fellow and a Senior Staff Fellow at NIMH. In 1998, she joined the faculty at the Pennsylvania State University in the Departments of Chemistry and Veterinary and Biomedical Sciences and was affiliated with the Huck Institutes Neuroscience and Molecular Toxicology Programs. Andrews is a member of the American Chemical Society, Society for Neuroscience, Society for Electroanalytical Chemistry, and the Serotonin Club. She has served on multiple review panels for the National Institute of Mental Health and the National Institute on Neurological Disorders and Stroke.
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Singh, Y. S., Sawarynski, L. E., Michael, H. M., Ferrell, R. E., Murphey-Corb, M. A., Swain, G. M., Patel, B. A., and Andrews, A. M., Boron-doped diamond microelectrodes reveal reduced rates of serotonin uptake in lymphocytes from adult rhesus carrying the short allele of the 5-HTTLPR, ACS Chemical Neuroscience, in press.
Luellen, B. A., Gillman, T. L., and Andrews, A. M. , "Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake" , Experimental Models in Serotonin Transporter Research, A. V. Kalueff and J. L. LaPorte, Eds., in press, Cambridge University Press: Cambridge. p. 1-42.
Daws, L. C., Andrews, A. M., Gerhardt, G. A. , "Electrochemical techniques and advances in psychopharmacology", Encyclopedia of Psychopharmacology, I.P.Stolerman, Ed., in press, Springer: New York.
Andrews, A. M., Does chronic antidepressant treatment increase extracellular serotonin?, Frontiers in Neuroscience, 2009, 3 (2), p. 246-247.
Shuster, M. J., Vaish, A., Szapacs, M. E., Anderson, M. E., Weiss, P. S., and Andrews, A. M., Biospecific recognition of tethered small molecules diluted in self-assembled monolayers, Advanced Materials, 2008, 20, p. 164-167.
Guiard, B. P., David, D. J., Deltheil, T., Chenu, F., Le Maitre, E., Renoir, T., Leroux-Nicollet, I., Sokoloff, P., Lanfumey, L., Hamon, M., Andrews, A. M., Hen, R., and Gardier, A. M., Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype, The International Journal of Neuropsychopharmacology, 2008, 11 ( 1), p. 79-92.
Murphy, D. L., Fox, M. A., Timpano, K. R., Moya, P. R., Ren-Patterson, R., Andrews, A. M., Holmes, A., Lesch, K. P., and Wendland, J. R., How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems, Neuropharmacology, 2008, 55 ( 6), 932-960.
Mullen, T. J., Srinivasan, C., Shuster, M. J., Horn, M. W., Andrews, A. M., and Weiss, P. S., Hybrid approaches to nanometer-scale patterning: Exploiting tailored intermolecular interactions, Journal of Nanoparticle Research, 2008, 10 ( 8), 1231-1240.
Perez, X. A., Bressler, A. J., and Andrews, A. M., "Determining serotonin and dopamine uptake rates in synaptosomes using high-speed chronoamperometry", Electrochemical Methods of Neurotransmitter Analysis, 2007, A.C. Michael and L.M. Borland, Eds.,CRC Press LLC: Boca Raton.
Fox, M. A., Andrews, A. M., Wendland, J. R., Lesch, K. P., Holmes, A., and Murphy, D. L., A pharmacological analysis of mice with a targeted disruption of the serotonin transporter, Pychopharmacology (Berl), 2007, 195 ( 2), 147-166.
Mullen, T. J., Srinivasan, C., Hohman, J. N., Gillmor, S. D., Shuster, M. J., Horn, M. W., Andrews, A. M., and Weiss, P. S., Microcontact insertion printing, Applied Physics Letters, 2007, 90 ( 6), p. 063114 (063111-063113).
Luellen, B. A., Bianco, L. E., Schneider, L. M., and Andrews, A. M. , Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice, Genes Brain and Behavior, 2007, 6, p. 482-490.
Srinivasan, C., Mullen, T. J., Hohman, J. N., Anderson, M. E., Dameron, A. A., Andrews, A. M., Dickey, E. C., Horn, M. W., and Weiss, P. S., Scanning electron microscopy of nanoscale chemical patterns, ACS Nano , 2007, 1 ( 3), p. 191-201.
Mullen, T. J., Dameron, A. A., Andrews, A. M., and Weiss, P. S. , Selecting and driving monolayer structures through tailored intermolecular interactions, Aldrichimica Acta, 2007, 40 ( 1), p. 21-31.
Counterman, A. E., D'Onofrio, T. G., Andrews, A. M., and Weiss, P. S., A physical model of axonal damage due to oxidative stress, Proceedings of the National Academy of Sciences of the United States of America, 2006, 103 ( 14), p. 5262-5266.
Perez, X. A., Bianco, L. E., and Andrews, A. M., Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: Comparison with chronoamperometry in SERT knockout mice, Journal of Neuroscience Methods, 2006, 154, p. 245-255.
Unger, E. L., Eve, D. J., Perez, X. A., Reichenbach, D. K., Xu, Y., Lee, M. K., and Andrews, A. M., Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice, Neurobiology Disease, 2006, 21 ( 2), p. 431-443.
Luellen, B. A., Szapacs, M. E., Materese, C. K., and Andrews, A. M., The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF, Neuropharmacology, 2006, 50 ( 3), p. 297-308.
Kim, D. K., Tolliver, T. J., Huang, S. J., Martin, B. J., Andrews, A. M., Wichems, C., Holmes, A., Lesch, K. P., and Murphy, D. L., Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter, Neuropharmacology, 2005, 49 ( 6), p. 798-810.
Perez, X. A. and Andrews, A. M., Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice, Analytical Chemistry, 2005, 77 ( 3), p. 818-826.
Szapacs, M. E., Numis, A. L., and Andrews, A. M., Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression, Journal of Neuroscience Methods, 2004, 140 ( 1-2), p. 81-92.
Mathews, T. A., Fedele, D. E., Coppelli, F. M., Avila, A. M., Murphy, D. L., and Andrews, A. M., Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression, Journal of Neuroscience Methods, 2004, 140 ( 1-2), p.169-181.
Szapacs, M. E., Numis, A. L., and Andrews, A. M. , Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1, Neurobiology of Disease, 2004, 16 ( 3), p. 572-580.
Numis, A. L., Unger, E. L., Sheridan, D. L., Chisnell, A. C., and Andrews, A. M., The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP), Molecular Pharmacology, 2004, 66 ( 3), p. 718-727.
Luellen, B. A., Miller, D. B., Chisnell, A. C., Murphy, D. L., O'Callaghan, J. P., and Andrews, A. M., Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine, Journal of Pharmacology Experimental Therapeutics, 2003, 307 ( 3), p. 923-931.
Unger, E. L., Mazzola-Pomietto, P., Murphy, D. L., and Andrews, A. M., 2'-NH(2)-MPTP [1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: A comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine], Journal Pharmacology and Experimental Therapeutics, 2002, 303 ( 2), p. 527-533.
Donovan, S. L., Mamounas, L. A., Andrews, A. M., Blue, M. E., and McCasland, J.S, GAP-43 is critical for normal development of the serotonergic innervation in forebrain, Journal of Neuroscience, 2002, 22 ( 9), p. 3543-3552.
Murphy, D. L., Li, Q., Engel, S., Wichems, C., Andrews, A., Lesch, K. P., and Uhl, G. , Genetic perspectives on the serotonin transporter, Brain Research Bulletin, 2001, 56 ( 5), p. 487-494.
Sora, I., Hall, F. S., Andrews, A. M., Itokawa, M., Li, X. F., Wei, H. B., Wichems, C., Lesch, K. P., Murphy, D. L., and Uhl, G. R., Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference, Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 ( 9), p. 5300-3055.
Andrews, A. M. , The use of 2'-NH2-MPTP as a tool to probe central serotonin and norepinephrine neurotransmitter systems, Neurotransmissions, 2000, 16, p.18-21.
Jayanthi, S., Ladenheim, B., Andrews, A. M., and Cadet, J. L., Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy), Neuroscience, 1999, 91 ( 4), p.1379-1387.
Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D., Heils, A., Mossner, R., Westphal, H., and Lesch, K. P., Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice, Molecular Pharmacology, 1998, 53 ( 4), p. 649-655.
Murphy, D. L., Andrews, A. M., Wichems, C. H., Li, Q., Tohda, M., and Greenberg, B., Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs, Journal of Clinical Psychiatry, 1998, 59 ( Suppl 15), p.4-12.
Tsao, L. I., Ladenheim, B., Andrews, A. M., Chiueh, C. C., Cadet, J. L., and Su, T. P., Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species, Journal of Pharmacology and Experimental Therapeutics, 1998, 287 ( 1), 322-331.
Bengel, D., Jöhren, O., Andrews, A. M., Heils, A., Mössner, R., Sanvitto, G. L., Saavedra, J. M., Lesch, K.-P., and Murphy, D. L., Cellular localization and expression of the serotonin transporter in mouse brain, Brain Research, 1997, 778 ( 2), p. 338-345.
Bengel, D., Heils, A., Petri, S., Seemann, M., Glatz, K., Andrews, A., Murphy, D. L., and Lesch, K. P., Gene structure and 5'-flanking regulatory region of the murine serotonin transporter, Brain Research: Molecular Brain Research, 1997, 44 ( 2), 286-92.
Tella, S. R., Ladenheim, B., Andrews, A. M., Goldberg, S. R., and Cadet, J. L., Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system, Journal Neuroscience, 1996, 16 ( 23), p. 7416-7427.
Andrews, A. M., Ladenheim, B., Epstein, C. J., Cadet, J. L., and Murphy, D. L., Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals, Molecular Pharmacology, 1996, 50 ( 6), p. 1511-1519.
Andrews, A. M. and Murphy, D. L., 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission., Journal of Pharmacology and Experimental Therapeutics, 1993, 267 ( 3), p. 1432-1439.
Andrews, A. M. and Murphy, D. L., Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine, European Journal of Pharmacology, 1993, 250 ( 2), p. 215-221.
Andrews, A. M. and Murphy, D. L., Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP, Journal of Neurochemistry, 1993, 60 ( 3), p. 1167-1170.
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