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Professor,
Psychiatry and Biobehavioral Sciences
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Member,
California NanoSystems Institute
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Education: |
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Degrees:
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Ph.D., The American University, 1993
B.S., The Pennsylvania State University, 1985
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Contact Information:
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Technical Research Interest:
Andrews’ group research is centered on understanding how serotonin modulates complex behaviors including anxiety, stress responsiveness, and learning and memory. Human and nonhuman primate cell lines expressing native serotonin transporter gene variants, genetically engineered mice, drugs, neurotoxins, and environmental factors are used to probe the molecular bases of serotonin system function, and the mechanisms of serotonergic drugs used to treat psychiatric disorders. Bioanalytical techniques, including microelectrode voltammetry and microdialysis are used to investigate serotonin neurotransmission. Neuronal architectures, neurogenesis, and the expression of key proteins, such as brain-derived neurotrophic factor, which are regulated by serotonin, are studied using autoradiography, immunocytochemistry, RT‑qPCR, ELISA and Western blotting. Neurotransmitter-functionalized self-assembled materials have been designed for fundamental studies on neurotransmitter recognition by native and nonnative biomolecule binding partners and for the development of novel in vivo nanobiosensors and functionally-directed proteomics.
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Singh, Y. S. Sawarynski, L. E. Michael, H. M. Ferrell, R. E. Murphey-Corb, M. A. Swain, G. M. Patel, B. A. Andrews, A. M. , Boron-doped diamond microelectrodes reveal reduced rates of serotonin uptake in lymphocytes from adult rhesus carrying the short allele of the 5-HTTLPR, ACS Chemical Neuroscience, volume (number), pages.
Mathews, T. A. Numis, A. L. Unger, E. L. Chisnell, A. C. Lee, M. K. Andrews, A. M. , Fatal motoric abnormalities in mice overexpressing mutant human A53T a-synuclein are not explained by altered dopamine neurotransmission, J Neurochem, volume (number), pages.
Unger, E. L. Pajtek, S. Zhao, M. K. Andrews, A. M. , Genetic predisposition to a lifetime of anxiety, secondary-title, volume (number), pages.
Mathews, T. A. Unger, E. L. Fedele, D. E. Coppelli, F. M. Gilman, T. L. Lesch, K-P. Murphy, D. L. Andrews, A. , MDMA-induced serotonin and dopamine release fails to stimulate locomotor activity in SERT deficient mice: Importance of desensitization of 5-HT1B receptors, Journal of Neuroscience, volume (number), pages.
Shen, Q. Lal, R. Luellen, B. A. Earnheart, J. C. Guo, Y. Andrews, A. M. LuÌscher, B. , Modest GABAA receptor deficit causes HPA axis hyperactivity and antidepressant drug sensitivity characteristic of melancholic and psychotic subtypes of depression, Biological Psychiatry, volume (number), pages.
Vaish, A. Shuster, M. J. Cheunkar, S. Singh, Y. S. Weiss, P. S. Andrews, A. M. , Native serotonin membrane receptors recognize 5-hydroxytryptophan-functionalized substrates: Enabling small-molecule recognition, ACS Chemical Neuroscience, volume (number), pages.
Bressler, A. J. Kovascics, C. Lewis, A. R. Jones, B. C. Vasudevan, N. Cavigelli, S. A. Andrews, A. M. , Segregating contextual versus social neophobia in two strains of BXD recombinant inbred mice, Genes Brain and Behavior, volume (number), pages.
Daws, L. C. Andrews, A. M. Gerhardt, G. A. , Electrochemical techniques and advances in psychopharmacology, Encyclopedia of Psychopharmacology, 2010, volume (number), pages.
Andrews, A. M. , Does chronic antidepressant treatment increase extracellular serotonin?, Frontiers in Neuroscience, 2009, 3 ( 2), pages.
Shuster, M. J. Vaish, A. Szapacs, M. E. Anderson, M. E. Weiss, P. S. Andrews, A. M. , Biospecific recognition of tethered small molecules diluted in self-assembled monolayers, Advanced Materials, 2008, 20 (number), 164-167.
Guiard, B. P. David, D. J. Deltheil, T. Chenu, F. Le Maitre, E. Renoir, T. Leroux-Nicollet, I. Sokoloff, P. Lanfumey, L. Hamon, M. Andrews, A. M. Hen, R. Gardier, A. M. , Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype, International Journal of Neuropsychopharmacology, 2008, 11 ( 1), 79-92.
Murphy, D. L. Fox, M. A. Timpano, K. R. Moya, P. R. Ren-Patterson, R. Andrews, A. M. Holmes, A. Lesch, K. P. Wendland, J. R. , How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems, Neuropharmacology, 2008, 55 ( 6), 932-60.
Mullen, T. J. Srinivasan, C. Shuster, M. J. Horn, M. W. Andrews, A. M. Weiss, P. S. , Hybrid approaches to nanometer-scale patterning: Exploiting tailored intermolecular interactions, Journal of Nanoparticle Research, 2008, 10 ( 8), 1231-1240.
Heien, M. L. Rice, M. E. Cremers, T. Michael, A. C. Andrews, A. M. , Making sense of biology: Special challenges associated with interpreting neurochemical data, 12th International Conference on In Vivo Methods, 2008, Monitoring Molecules in Neuroscience. Proceedings of the 12th International Conference on In Vivo Methods (number), pages.
Fox, M. A. Andrews, A. M. Wendland, J. R. Lesch, K. P. Holmes, A. Murphy, D. L. , A pharmacological analysis of mice with a targeted disruption of the serotonin transporter, Psychopharmacology (Berl), 2007, 195 ( 2), 147-66.
Luellen, B. A. Bianco, L. E. Schneider, L. M. Andrews, A. M. , Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice, Genes Brain and Behavior, 2007, 6 (number), 482-490.
Srinivasan, C. Mullen, T. J. Hohman, J. N. Anderson, M. E. Dameron, A. A. Andrews, A. M. Dickey, E. C. Horn, M. W. Weiss, P. S. , Scanning electron microscopy of nanoscale chemical patterns, ACS Nano, 2007, 1 ( 3), 191-201.
Mullen, T. J. Dameron, A. A. Andrews, A. M. Weiss, P. S. , Selecting and driving monolayer structures through tailored intermolecular interactions, Aldrichimica Acta, 2007, 40 ( 1), 21-31.
Mullen, T. J. Srinivasan, C. Hohman, J. N. Gillmor, S. D. Shuster, M. J. Horn, M. W. Andrews, A. M. Weiss, P. S. , Microcontact insertion printing, Applied Physics Letters, 2007, 90 ( 6), 063114 (1-3).
Unger, E. L. Eve, D. J. Perez, X. A. Reichenbach, D. K. Xu, Y. Lee, M. K. Andrews, A. M. , Locomotor hyperactivity and alterations in dopamine neurotransmission are associated with overexpression of A53T mutant human alpha-synuclein in mice, Neurobiol Dis, 2006, 21 ( 2), 431-43.
Mathews, T. A. Unger, E. L. Fedele, D. E. Lesch, K. -P. Murphy, D. L. Andrews, A. M. , MDMA-induced dopamine and serotonin release does not stimulate locomotor activity in SERT knockout mice: importance of 5-HT1B receptors, 11th International Conference on In Vivo Methods, 2006, Monitoring Molecules in Neuroscience. Proceedings of the 11th International Conference on In Vivo Methods (number), pages.
Luellen, B. A. Szapacs, M. E. Materese, C. K. Andrews, A. M. , The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes increases in hippocampal BDNF, Neuropharmacology, 2006, 50 ( 3), 297-308.
Counterman, A. E. D'Onofrio, T. G. Andrews, A. M. Weiss, P. S. , A physical model of axonal damage due to oxidative stress, Proc Natl Acad Sci U S A, 2006, 103 ( 14), 5262-6.
Perez, X. A. Bianco, L. E. Andrews, A. M. , Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: Comparison with chronoamperometry in SERT knockout mice, Journal of Neuroscience Methods, 2006, 154 (number), 245-255.
Kim, D. K. Tolliver, T. J. Huang, S. J. Martin, B. J. Andrews, A. M. Wichems, C. Holmes, A. Lesch, K. P. Murphy, D. L. , Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter, Neuropharmacology, 2005, 49 ( 6), 798-810.
Perez, X. A. Andrews, A. M. , Chronoamperometry to determine differential reductions in uptake in brain synaptosomes from serotonin transporter knockout mice, Analytical Chemistry, 2005, 77 ( 3), 818-26.
Szapacs, M. E. Numis, A. L. Andrews, A. M. , Late onset loss of hippocampal 5-HT and NE is accompanied by increases in BDNF protein expression in mice co-expressing mutant APP and PS1, Neurobiol Dis, 2004, 16 ( 3), 572-80.
Numis, A. L. Unger, E. L. Sheridan, D. L. Chisnell, A. C. Andrews, A. M. , The role of membrane and vesicular monoamine transporters in the neurotoxic and hypothermic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH(2)-MPTP), Mol Pharmacol, 2004, 66 ( 3), 718-27.
Szapacs, M. E. Mathews, T. A. Tessarollo, L. Ernest Lyons, W. Mamounas, L. A. Andrews, A. M. , Exploring the relationship between serotonin and brain-derived neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT in mice with reduced serotonin transporter or BDNF expression, Journal of Neuroscience Methods, 2004, 140 ( 1-2), 81-92.
Mathews, T. A. Fedele, D. E. Coppelli, F. M. Avila, A. M. Murphy, D. L. Andrews, A. M. , Gene dose-dependent alterations in extraneuronal serotonin but not dopamine in mice with reduced serotonin transporter expression, Journal of Neuroscience Methods, 2004, 140 ( 1-2), 169-81.
Luellen, B. A. Miller, D. B. Chisnell, A. C. Murphy, D. L. O'Callaghan, J. P. Andrews, A. M. , Neuronal and astroglial responses to the serotonin and norepinephrine neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine, J Pharmacol Exp Ther, 2003, 307 ( 3), 923-31.
Mathews, T. A. Perez, X. A. Unger, E. L. Szapacs, M. E. Luellen, B. A. Andrews, A. M. , SERT as a key regulator of serotonergic signaling and the effects on anxiety-related behavior, 10th International Conference on In Vivo Methods, 2003, Monitoring Molecules in Neuroscience. Proceedings of the 10th International Conference on In Vivo Methods (number), 383-385.
Unger, E. L. Mazzola-Pomietto, P. Murphy, D. L. Andrews, A. M. , 2'-NH(2)-MPTP [1-Methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine] depletes serotonin and norepinephrine in rats: A comparison with 2'-CH(3)-MPTP [1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine], J Pharmacol Exp Ther, 2002, 303 ( 2), 527-33.
Donovan, S. L. Mamounas, L. A. Andrews, A. M. Blue, M. E. McCasland, J. S. , GAP-43 is critical for normal development of the serotonergic innervation in forebrain, J Neurosci, 2002, 22 ( 9), 3543-52.
Fedele, D. E. Mathews, T. A. Andrews, A. M. , Quantitative microdialysis for serotonin in striatum and frontal cortex of genetically altered mice, 9th International Conference on In Vivo Methods, 2001, Monitoring Molecules in Neuroscience. Proceedings of the 9th International Conference on In Vivo Methods (number), 97-98.
Murphy, D. L. Li, Q. Engel, S. Wichems, C. Andrews, A. Lesch, K. P. Uhl, G. , Genetic perspectives on the serotonin transporter, Brain Res Bull, 2001, 56 ( 5), 487-94.
Sora, I. Hall, F. S. Andrews, A. M. Itokawa, M. Li, X. F. Wei, H. B. Wichems, C. Lesch, K. P. Murphy, D. L. Uhl, G. R. , Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference, Proceedings of the National Academy of Sciences of the United States of America, 2001, 98 ( 9), 5300-5.
Andrews, A. M. , The use of 2â-NH2-MPTP as a tool to probe central serotonin and norepinephrine neurotransmitter systems, Neurotransmissions, 2000, 16 (number), 18-21.
Fedele, D. E. Andrews, A. M. , A microdialysis study of the effects of genetic inactivation of the serotonin transporter gene on baseline and K+-stimulated extracellular serotonin concentrations in mouse striatum, 8th International Conference on In Vivo Methods, 1999, Monitoring Molecules in Neuroscience. Proceedings of the 8th International Conference on In Vivo Methods (number), 193-194.
Jayanthi, S. Ladenheim, B. Andrews, A. M. Cadet, J. L. , Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy), Neuroscience, 1999, 91 ( 4), 1379-87.
Bengel, D. Murphy, D. L. Andrews, A. M. Wichems, C. H. Feltner, D. Heils, A. Mossner, R. Westphal, H. Lesch, K. P. , Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice, Molecular Pharmacology, 1998, 53 ( 4), 649-55.
Murphy, D. L. Andrews, A. M. Wichems, C. H. Li, Q. Tohda, M. Greenberg, B. , Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs, J Clin Psychiatry, 1998, 59 ( Suppl 15), 4-12.
Tsao, L. I. Ladenheim, B. Andrews, A. M. Chiueh, C. C. Cadet, J. L. Su, T. P. , Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species, Journal of Pharmacology and Experimental Therapeutics, 1998, 287 ( 1), 322-31.
Bengel, D. Jöhren, O. Andrews, A. M. Heils, A. MöÃner, R Sanvitto, G. L. Saavedra, J. M. Lesch, K. -P. Murphy, D. L. , Cellular localization and expression of the serotonin transporter in mouse brain, Brain Research, 1997, 778 ( 2), 338-45.
Bengel, D. Heils, A. Petri, S. Seemann, M. Glatz, K. Andrews, A. Murphy, D. L. Lesch, K. P. , Gene structure and 5'-flanking regulatory region of the murine serotonin transporter, Brain Research Molecular Brain Research, 1997, 44 ( 2), 286-92.
Andrews, A. M. Ladenheim, B. Epstein, C. J. Cadet, J. L. Murphy, D. L. , Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals, Mol Pharmacol, 1996, 50 ( 6), 1511-9.
Tella, S. R. Ladenheim, B. Andrews, A. M. Goldberg, S. R. Cadet, J. L. , Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system, Journal Neuroscience, 1996, 16 ( 23), 7416-27.
Andrews, A. M. Murphy, D. L. , 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission, J Pharmacol Exp Ther, 1993, 267 ( 3), 1432-9.
Andrews, A. M. Murphy, D. L. , Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP, J Neurochem, 1993, 60 ( 3), 1167-70.
Andrews, A. M. , The neurotoxic effects of 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP) on brain serotonin and norepinephrine in mice, Chemistry, 1993, Ph.D. (number), 137.
Andrews, A. M. Murphy, D. L. , Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine, Eur J Pharmacol, 1993, 250 ( 2), 215-21.
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