California NanoSystems Institute

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Michael Teitell, M.D., Ph.D.

Professor, Pediatrics, Pathology and Laboratory Medicine

Member, California NanoSystems Institute

Education:

Degrees:

Ph.D., UCLA, 1991
M.S., UCLA, 1985
B.S., UCLA, 1985

M.D.:

1993 UCLA School of Medicine, Medicine

Certifications:

Certifications:

2001 American Board of Pathology
1997 American Board of Pathology

Honors and Awards:

ASCI, 2004 American Society of Clinical Investigators
Genomics Research, 2001 Millenium Pharmaceuticals
Leukemia and Lymphoma Society, 2003 Scholar Award
Lymphoma Research Foundation, Junior Faculty Award (2001)
2004 - Elliot Osserman Award in Support of Cancer Research
1999 - Lymphoma Research Foundation of America Fellow

Professional Societies:

American Association for Cancer Research (AACR)
American Association of Immunologists (AAI)
American Society for Biochemistry and Molecular Biology (ASBMB)
American Society of Clinical Investigators
California NanoSystems Institute (CNSI)
Institute for Cell Mimetic Space Exploration (CMISE)
Institute for Stem Cell Biology and Medicine (ISCBM)
Jonsson Comprehensive Cancer Center
Molecular Biology Institute
Sigma Xi Scientific Society
UCLA AIDS Research Institute
UCLA Association of Chemists and Biochemists

Contact Information:

Work Email Address:	mteitell@mednet.ucla.edu

Work Address:	Office 675 Charles Young Drive South Westwood, CA 90095 UNITED STATES

Home Page:	http://www.Teitell-Lab.com
ARR Papers:	http://www.cnsi.ucla.edu/arr/personnel-papers?personnel_id=9524

Fax Number:	(310) 267-0382
Work Phone Number:	(310) 206-6754 office (310) 206-6821 lab

Technical Research Interest:

The Teitell lab is interested in the etiology, mechanism, and therapy of immune system cancers, normal immune system development, and the generation of novel investigative nanotools. One project area focuses on epigenetic silencing of gene expression. The rules that govern silencing, the patterns of epigenetic marks in normal and malignant situations, and the targeting of epigenetic enzymes to specific genome regions are being investigated. A second project area is in the biology of the TCL1 oncogene, which was discovered during a screening survey for genes that could promote B cell lymphoma formation. A third area of work involves studies on a novel type of RNA degradation that regulates cell metabolism and survival leading to cancerous transformation. A fourth project area is in collaboration with a group of talented physicists and engineers to design new methods for interrogating cell motion and development of new tools to evaluate cell functions in real-time. These distinct areas of study all converge on the common goal of increased understanding, diagnosis and treatment of human malignancies in the context of changes that arise compared with normal development and function.

For more information, please visit the Teitell Lab web site: www.Teitell-Lab.com.

Additional Information:

Michael A. Teitell is an immunologist and cancer biologist who has been on the UCLA School of Medicine faculty since joining the Departments of Pathology/Laboratory Medicine and Pediatrics in 1999. He has been Chief of the Division of Pediatric and Developmental Pathology since 2001 and was promoted to Associate Professor of Pathology and Pediatrics in 2004. Dr. Teitell earned B.S. and M.S. combined degrees as a Departmental Scholar in Biochemistry from UCLA in 1985, and earned combined M.D. and Ph.D. degrees from the UCLA Medical Scientist Training Program in 1993. His Ph.D. studies were in molecular and cellular immunology. He performed residencies in Anatomic Pathology at Harvard/Brigham and Women's Hospital and Clinical Pathology at UCSF and a fellowship in Pediatric Pathology at Children's Hospital Los Angeles. He is board-certified in each of these pathology specialties. He was a postdoctoral fellow at UCLA, Harvard/BWH and UCSF before returning to UCLA as a Clinical Instructor in Pathology in 1999. Dr. Teitell is co-Director of the UCLA T32 Tumor Immunology Training Grant and serves on the MSTP Executive and Admissions Committees and the UCLA Academic Senate Committee on Library. His awards include a FOCIS/Millenium Pharmaceuticals Award for Genomics Research, two awards from the Lymphoma Research Foundation, an award from the Margaret Early Medical Research Trust and the Leukemia and Lymphoma Society Scholar Award. He was elected to the American Society of Clinical Investigators (ASCI) in 2004. His laboratory research centers on signal transduction and epigenetics of immune system development and cancer, as well as developing new approaches to problems in cancer biology using nanoscale methods. His group created the first genetic animal model for germinal center based B cell lymphomas that accurately resemble the majority of lymphocyte cancers afflicting humans.

Selected Publications:

Balatoni,C. E.; Dawson, D. W.; Suh,J.; Sherman,M.H.; Sanders, G.; Hong,J.S.; Frank,M.J.; Malone, C.S.; Said,J.W. and Teitell, M.A. , Epigenetic Silencing of Stk39 in B-Cell Lymphoma Inhibits Apoptosis from Genotoxic Stress , Am. J. Pathol., 2009, 175, 1653-1661.

Frank, M. J. Dawson, D. W. Bensinger, S. J. Hong, J. S. Knosp, W. M. Xu, L. Balatoni, C. E. Allen, E. L. Shen, R. R. Bar-Sagi, D. Martin, G. R. Teitell, M. A. , Expression of sprouty2 inhibits B-cell proliferation and is epigenetically silenced in mouse and human B-cell lymphomas, Blood, 2009, 113 (11), 2478-87.

Hao Wu, Kevin J. Kim, Kshama Mehta, Salvatore Paxia, Andrew Sundstrom, Thomas Anantharaman, Ali I. Kuraishy, Tri Doan, Jayati Ghosh, April D. Pyle, Amander Clark, William Lowry, Guoping Fan, Tim Baxter, Bud Mishra, Yi Sun, Michael A. Teitell , Copy Number Variant Analysis of Human Embryonic Stem Cells , Stem Cells, 2008.

Reed, J., Frank, M., Troke, J. J., Schmit, J., Han, S., Teitell, M. A., and Gimzewski, J. K., High throughput cell nanomechanics with mechanical imaging interferometry, Nanotechnology, 2008, 19.

Reed, J., Troke, J. J., Schmit, J., Han, S., Teitell, M. A. and Gimzewski, J. K., Live Cell Interferometry Reveals Cellular Dynamism During Force Propagation, ACS Nano, 2008, 2 (5), 841–846.

Pelling, A.E., Dawson, D.W., Carreon, D.M., Christiansen, J.J., Shen, R.R., Teitell, M.A. and Gimzewski, J.K., "Distinct Contributions of Microtubule Subtypes to Cell Membrane Shape and Stability", Nanomedicine, 2007, 3 (1), 43-52.

Weihs, D., Mason, T.G., and Teitell, M.A., Effects of Cytoskeletal Disruption on Transport, Structure, and Rheology within Mammalian Cells. (Submitted), , 2007.

Memarzadeh, S., Xin, L., Mulholland, D.J., Mansukhani, A., Wu, H., Teitell, M.A., and Witte, O.N. , Enhanced Paracrine FGF10 Expression Promotes Formation of Multifocal Prostate Adenocarcinoma and an Increase in epithelial Androgen Receptor, (Submitted), , 2007.

Chen, H. W. Koehler, C. M. Teitell, M. A. , Human polynucleotide phosphorylase: location matters, Trends Cell Biol, 2007, 17 (12), 600-8.

Zhou, H., Miki, R., Eeva, M., Fike, F.M., Seligson, D., Yang, L., Yoshimura, A., Teitell, M.A., Jamieson, C.A.M. and Cacalano, N.A., Reciprocal Regulation of SOCS1 and SOCS3 Enhances Resistance to Ionizing Radiation in Glioblastoma Multiforme, Clinical Cancer Research, 2007, 13 (8), 2344-53.

Smiraglia, D.J., Kazhiyur-Mannar, R., Oackes, C.C., Wu, Y.-Z., Hall, J., Liang, P., Rush, L., Smith, L., Yu, L., Liu, C., Dai, Z., Costello, J., Chen, S.-S., Wang, S.-H., Ioschikhes, I., Dawson, D.W., Hong, J.S., Teitell, M.A., Szafranek, A., Camoriano, M., Song, F., Elliot, R., Held, W., Trasler, J.M., Wenger, R., and Plass, C. , Restriction Landmark Genomic Scanning (RLGS) Spot Identification by Second Generation Virtual RLGS in Multiple Genomes with Multiple Enzyme Combinations, (Submitted), , 2007.

Weihs, D., Teitell, M.A., and Mason, T.G., Simulations of Complex Particle Transport in Heterogeneous Active Liquids, Microfluidics & Nanofluidics, 2007, 3 (2), 227-237.

Reed, J., Mishra, B., Pittenger, B., Magonov, S., Troke, J.J., Teitell, M.A. and Gimzewski, J.K., Single Molecule Transcription Profiling with AFM, Nanotechnology, 2007, 18, 1-15.

Kuraishy, A.I., French, S.W., Sherman, M., Herling, M., Jones, D., Wall, R., and Teitell, M.A., TORC2 Regulates Germinal Center Repression of the TCL1 Oncoprotein to Promote B Cell Development and Inhibit Transformation, Proceedings of the National Academy of Sciences, 2007, In Press.

French, S.W., Dawson, D.W., Chen, H.-W., Rainey, R.N., Sievers, S.A., Balatoni, C.E., Wong, L., Troke, J.J., Nyugen, M.T.N., Koehler, C.M., and Teitell, M.A., The TCL1 Oncoprotein Binds the RNase PH Domains of the PNPase Exoribonuclease Without Affecting its RNA Degrading Activity, Cancer Letters, 2007, 248 (2), 198-210.

Yang LV, Radu CG, Roy M, Lee S, McLaughlin J, Teitell MA, Iruela-Arispe ML, Witte ON, Vascular Abnormalities in Mice Deficient for the G-Protein Coupled Receptor GPR4 that Functions as a pH Sensor., Molecular and Cellular Biology, 2007, 27 (4), 1334-47.

Morse III HC, Ward JM and Teitell MA, "Animal Models of Human B Lymphoid Neoplasms", In Magrath, I: The Lymphoid Neoplasms, 1st Ed., London, Arnold, 2006, In Press.

Weihs D, Mason TG, and Teitell MA, "Bio-microrheology: A Frontier in Microrheology", Biophysical Journal, 2006, 91 (11), 4296-4305.

Shen RR, Ferguson DO, Renard M, Hoyer KK, Kim U, Hao X, Alt FW, Roeder RG, Morse III HC, and Teitell MA, "Dysregulated TCL1 Requires the Germinal Center and Genome Instability for Mature B Cell Transformation", Blood, 2006, 108 (6), 1991-1998.

Estep AL, Tidyman WE, Teitell MA, Cotter PD and Rauen KA, "HRAS Mutations in Costello Syndrome: Detection of Constitutional Activating Mutations in Codon 12 and 13 and Loss of Heterozygosity in Malignancy", American Journal of Medical Genetics, 2006, 140 (1), 8-16.

Ouyang Y, Kwon YT, An JY, Eller D, Tsai SC, Diaz-Perez S, Troke JJ, Teitell MA and Marahrens Y, "Loss of Ubr2, an E3 Ubiquitin Ligase, Leads to Chromosome Fragility and Impaired Homologous Recombinational Repair", Mutation Research, 2006, 596 ((1-2)), 64-75.

Chen HW, Rainey RN, Balatoni CE, Dawson DW, Troke JJ, Wasiak S, Hong J, McBride H, Koehler CM, Teitell MA, and French SW, "Mammalian PNPase is an Intermembrane Space Ribonuclease that Maintains Mitochondrial Homeostasis", Molecular and Cellular Biology, 2006, 26 (22), 8475-87.

Xin L, Teitell M, Lawson DA, Kwon A, Mellinghoff IK and Witte ON, "Progression of Prostate Cancer by Synergy of AKT with Genotropic and Nongenotropic Actions of the Androgen Receptor, PNAS, 2006, 103 (20), 7789-7794.

Teitell MA and Mikkola HKA, "Transcriptional Activators and Repressors During Hematopoietic Stem Cell Development", Pediatric Research, 2006, 59 (4 pt 2), 33R-39R.

Diaz-Perez, S., Ferguson, D.O., Wang, C., Csankovszki, G., Wang, C., Tsai, S.-C., Dutta, D., Perez, V., Kim, S., Eller, C.D., Salstrom, J., Ouyang, Y., Teitell, M.A., Kaltenboeck, B., Chess, A., Huang, S., and Marahrens, Y., A Deletion at the Mouse Xist Gene Exposes Trans-Effects that Alter the Heterochromatin of the Inactive X Chromosome and the Replication Time and DNA Stability of Both X Chromosomes, Genetics, 2006, 174, 1115-1133.

Malone, C.S., Kuraishy, A.I., Fike, F.M., Loya, R.G., Mikkili, M.R., Teitell, M.A., and Wall, R., B29 Gene Silencing in Pituitary Cells is Regulated by Its 3�� Enhancer, Journal of Molecular Biology, 2006, 362, 173-183.

Weihs, D. Mason, T. G. Teitell, M. A. , Bio-microrheology: a frontier in microrheology, Biophys J, 2006, 91 (11), 4296-305.

Kuraishy, A.I., French, S.W., Herling, M., Jones, D., and Teitell, M.A., CREB and TORC2 Transactivate TCL1 Proto-Oncogene Expression in B Cells, Submitted, , 2006.

Wiebers, J., Teitell, M., Gomperts, B., and Milisavljevic, V. , Congenital High Grade Sarcoma with t(9;22) Characteristic of Extreaskeletal Myxoid Chondrosarcoma: A Case report and Literature Review, Submitted, , 2006.

Xu, J., Gowen, L., Raphalides, C., Hoyer, K.K., Weinger, J.G., Renard, M., Troke, J.J., Vaitheesyaran, B., Lee, W.N.P., Saad, M.F., Sleeman, M.W., Teitell, M.A. and Kurland, I.J., Decreased Hepatic Futile Cycling Compensates for Increased Glucose Disposal in the PTEN Hetero-Deficient Mouse, Diabetes, 2006, 55, 3372-3380.

Moore, M.L., Teitell, M.A., Kim, Y., Watabe, T., Reiter, R.E., Witte, O.N., and Dubey, P. , Deletion of PSCA Increases Metastasis of Prostate Tumors Without Altering Primary Tumor Formation, (Submitted), , 2006.

Chen, H. W. Rainey, R. N. Balatoni, C. E. Dawson, D. W. Troke, J. J. Wasiak, S. Hong, J. S. McBride, H. M. Koehler, C. M. Teitell, M. A. French, S. W. , Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis, Mol Cell Biol, 2006, 26 (22), 8475-87.

Henson, S.E., Tsai, S. C., Malone, C.S., Soghomonian, S.V., Ouyang, Y., Wall, R., Marahrens, Y., and Teitell, M.A., Pir51, a Rad51-Interacting Protein with High Expression in Aggressive Lymphoma, Controls Mitomycin C Sensitivity and Prevents Chromosomal Breaks, Mutation Research, 2006, 601, 113-124.

Xin L, Teitell MA, Lawson DA, Kwon A, Mellinghoff IK and Witte ON, Progression of Prostate Cancer by Synergy of AKT with Genotropic and Non-Genotropic Action of the Androgen Receptor, Proceedings of the National Academy of Sciences USA, 2006, 103 (20), 7789-94.

Herling, M., Patel, K., Teitell, M.A., Konopleva, M., Ravandi, F.; Kobayashi, R., and Jones, D., Transient Activation-Induced TCL1-AKT Complexes and their Effects on T-Cell Leukemia Growth, Submitted, , 2006.

McWhorter V, Dunn J and Teitell MA, "Aortoesophageal Fistula as a Complication of Montgomery Salivary Bypass Tube", Journal of Pediatric Surgery, 2005, 40 (4), 742-744.

Liu B, Yang R, Wong KA, Getman C, Stein N, Teitell MA, Cheng G, Wu H and Shuai K, "Negative Regulation of NF-KB Signaling by PIAS1", Molecular and Cellular Biology, 2005, 25 (3), 1113-1123.

Teitell MA, "TCL1 Family Oncoproteins: Co-activators of Transformation", Nature Reviews Cancer , 2005, 5 (8), 640-648.

Hoyer KK, Herling M, Dawson DW, Renard M, Weinger JG, Jones D and Teitell MA, "TCL1 Modulates TCR Signal Strength and IFNg Levels Through PI3K and PKC Pathway Activation", Journal of Immunology, 2005, 175 (2), 864-873.

Dovat S, Montecino-Rodriguez E, Schuman V, Teitell MA, Dorshkind K, and Smale ST, "Transgenic Expression of Helios in B-Lineage Cells Alters B-Cell Properties and Promotes Lymphomagenesis", Journal of Immunology, 2005, 175 (6), 3508-3515.

Esteve P, Patnaik D, Chin H, Benner J, Teitell MA and Pradhan S , Functional Analysis of the Amino and Carboxy Terminus of Mammalian G9a Histone H3 Methyltransferase, Nucleic Acids Research, 2005, 33, 3211-3223.

Gimzewski JK, Reed J, Teitell MA and Malan PG, Immunological Biosensors, In Wild, D: The Immunoassay Handbook, 3rd Ed, 2005, 265-280.

Ouyang Y, Salstrom J, Diaz-Perez S, Nahas S, Matsuno Y, Dawson D, Teitell MA, Horvath S, Riggs AD, Gatti RA, Marahrens Y , Inhibition of Atm and/or Atr disrupts gene silencing on the inactive X chromosome, Biochem Biophys Res Commun, 2005, 337 (3), 875-80.

Hinek A, Teitell M, Schoyer L, Allen W, Gripp KW, Hamilton R, Weksberg R and Lin AE, Myocardial Storage of Chondroitin Sulfate -Containing Moieties in Costello Syndrome Patients with Severe Hypertrophic Cardiomyopathy, American Journal of Medical Genetics, 2005, 133A, 1-12.

Doerr JR, Malone CS, Fike FM, Gordon MS, Soghomonian SV, Thomas RK, Tao Q, Murray PG, Diehl V, Teitell MA, Wall R, Patterned CpG methylation of silenced B cell gene promoters in classical Hodgkin lymphoma-derived and primary effusion lymphoma cell lines., Journal of molecular biology. , 2005, 350 (4), 631-40.

Lin HM, Teitell MA, Second malignancy after treatment of pediatric Hodgkin disease., Journal of pediatric hematology/oncology : official journal of the American Society of Pediatric Hematology/Oncology. , 2005, 27 (1), 28-36.

Hoyer, K. K. Herling, M. Bagrintseva, K. Dawson, D. W. French, S. W. Renard, M. Weinger, J. G. Jones, D. Teitell, M. A. , T cell leukemia-1 modulates TCR signal strength and IFN-gamma levels through phosphatidylinositol 3-kinase and protein kinase C pathway activation, J Immunol, 2005, 175 (2), 864-73.

Teitell MA, Lones MA, Perkins SL, Sanger WG, Cairo MS, Said JW, TCL1 expression and Epstein-Barr virus status in pediatric Burkitt lymphoma., American journal of clinical pathology. , 2005, 124 (4), 569-75.

Lin MZ, Teitell MA, Schiller GJ, The evolution of antibodies into versatile tumor-targeting agents., Clinical cancer research : an official journal of the American Association for Cancer Research. , 2005, 11 (1), 129-38.

Petrella T, Teitell M, Spiekermann C, Meijer CJLM, Franck F, and Enache I, "A CD56-Negative Case of Blastic NK Cell Lymphoma (Agranular CD4+/CD56+ Hematodermic Neoplasia)", British Journal of Dermatology, 2004, 150 (1), 174-176.

Hoyer KK, Pang M, Gui D, Shintaku IP, Kuwabara I, Liu FT, Said JW, Baum LG, and Teitell MA, "An Anti-Apoptotic Role for Galectin-3 in Diffuse Large B Cell Lymphomas", American Journal of Pathology, 2004, 164 (3), 893-902.

Petrella T, Meijer CJLM, Dalac S, Willemze R, Maynadie M, Machet L, Casasnovas O, Vergier B, and Teitell MA, "TCL1 and CLA Expression in CD4/CD56 Hematodermic Neoplasms (Blastic NK-Cell Lymphomas) and Leukemia Cutis", American Journal of Clinical Pathology, 2004, 122 (2), 307-313.

Teitell MA, Pandolfi PP, Lymphoid Malignancies., Mouse Models of Human Cancer, 2004, 1, 237-259.

Teitell, M. A., T Cells in Mouse Follicular Lymphoma, Blood, 2004, 106 (1981-1982).

Patrone L, Henson SE, Teodorovic J, French SW, Wall R and Teitell MA , "Gene Expression Profile for AIDS-Related Non-Hodgkin Lymphoma", Experimental and Molecular Pathology, 2003, 74 (2), 129-139.

Teitell MA, "OCA-B Regulation of B Cell Development and Function", Trends in Immunology, 2003, 24 (10), 546-553.

Herling M, Teitell MA, Shen RR, Medeiros LJ, and Jones D, "TCL1 Expression in Plasmacytoid Dendritic Cells (DC2) and the Related CD4+ CD56+ Blastic Tumors of Skin", Blood, 2003, 101 (12), 5007-5009.

Teitell MA, "TCL1", Creighton, T.E.: Wiley's Encyclopedia of Molecular Medicine, 1st Ed., New York, J. Wiley & Sons, 2002, 3106-3108.

French SW, Dawson DW, Miner MD, Doerr JR, Malone CS, Wall R, Teitell MA, DNA methylation profiling: a new tool for evaluating hematologic malignancies., Clinical immunology (Orlando, Fla.) , 2002, 103 (3 Pt 1), 217-30.

Hoyer, K. K. French, S. W. Turner, D. E. Nguyen, M. T. Renard, M. Malone, C. S. Knoetig, S. Qi, C. F. Su, T. T. Cheroutre, H. Wall, R. Rawlings, D. J. Morse, H. C., 3rd Teitell, M. A. , Dysregulated TCL1 promotes multiple classes of mature B cell lymphoma, Proc Natl Acad Sci U S A, 2002, 99 (22), 14392-7.

Teitell M, MTCP1 (Mature T Cell Proliferation-1), Wiley's Encyclopedia of Molecular Medicine, 2002, 3, 2136-2137.

Su TT, Guo B, Kawakami Y, Chae K, Humphries LA, Kato RM, Kang S, Wall R, Teitell M, Leitges M, Kawakami T and Rawlings DJ, PKCB Controls BCR Mediated NFKB Signaling by Regulating IKB Kinase Recruitment into Lipid Rafts, Nature Immunology, 2002, 3, 780-786.

Teitell M, TCL1 (T-cell leukemia-1), Wiley's Encyclopedia of Molecular Medicine, 2002, 5, 3105-3107.

French SW, Hoyer KK, Shen RR, Teitell MA, Transdifferentiation and nuclear reprogramming in hematopoietic development and neoplasia., Immunological reviews. , 2002, 187, 22-39.

Arvand, A. Welford, S. M. Teitell, M. A. Denny, C. T. , The COOH-terminal domain of FLI-1 is necessary for full tumorigenesis and transcriptional modulation by EWS/FLI-1, Cancer Res, 2001, 61 (13), 5311-7.